Yap enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation
文献类型：期刊论文
| 作者 | Song, Qinghe1,2; Mao, Beibei1; Cheng, Jinbo1; Gao, Yuhao1,2; Jiang, Ke3; Chen, Jun4; Yuan, Zengqiang1,2; Meng, Songshu3 |
| 刊名 | Plos one
 |
| 出版日期 | 2015-03-26 |
| 卷号 | 10期号:3页码:17 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0120790 |
| 通讯作者 | Yuan, zengqiang(zqyuan@ibp.ac.cn) |
| 英文摘要 | The yes-associated protein (yap), a transcriptional coactivator inactivated by the hippo tumor suppressor pathway, functions as an oncoprotein in a variety of cancers. however, its contribution to breast cancer remains controversial. this study investigated the role of yap in breast cancer cells under nutrient deprivation (nd). here, we show that yap knockdown sensitized mcf7 breast cancer cells to nutrient deprivation-induced apoptosis. furthermore, in response to nd, yap increased the autolysosome degradation, thereby enhancing the cellular autophagic flux in breast cancer cells. of note, autophagy is crucial for yap to protect mcf7 cells from apoptosis under nd conditions. in addition, the tea domain (tead) family of growth-promoting transcription factors was indispensable for yap-mediated regulation of autophagy. collectively, our data reveal a role for yap in promoting breast cancer cell survival upon nd stress and uncover an unappreciated function of yap/tead in the regulation of autophagy. |
| WOS关键词 | HIPPO SIGNALING PATHWAY ; INHIBITS AUTOPHAGY ; HETEROZYGOSITY ; APOPTOSIS ; PROTEIN ; PROLIFERATION ; DEATH ; LC3 ; IDENTIFICATION ; TUMORIGENESIS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000356353700061 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376415 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yuan, Zengqiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 3.Dalian Med Univ, Ctr Canc, Inst Canc Stem Cell, Dalian, Liaoning, Peoples R China 4.Sichuan Univ, Coll Life Sci, Ctr Growth Metab & Aging, Chengdu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Qinghe,Mao, Beibei,Cheng, Jinbo,et al. Yap enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation[J]. Plos one,2015,10(3):17. |
| APA | Song, Qinghe.,Mao, Beibei.,Cheng, Jinbo.,Gao, Yuhao.,Jiang, Ke.,...&Meng, Songshu.(2015).Yap enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation.Plos one,10(3),17. |
| MLA | Song, Qinghe,et al."Yap enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation".Plos one 10.3(2015):17. |
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来源：中国科学院大学
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