Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach
文献类型：期刊论文
| 作者 | Yao, Xuan1,2,3; Sa, Rina1,2; Ye, Cheng1,2; Zhang, Duo1,2; Zhang, Shengjie1,2; Xia, Hongfeng1,2; Wang, Yu-Cheng3,4; Jiang, Jingjing5; Yin, Huiyong1,2; Ying, Hao1,2,3 |
| 刊名 | Prostaglandins & other lipid mediators
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 118页码:11-18 |
| 关键词 | Arachidonic acid metabolites Targeted metabolomic approach Hypothyroidism Hyperthyroidism Cardiovascular disorders |
| ISSN号 | 1098-8823 |
| DOI | 10.1016/j.prostaglandins.2015.03.005 |
| 通讯作者 | Ying, hao(yinghao@sibs.ac.cn) |
| 英文摘要 | Symptoms of cardiovascular diseases are frequently found in patients with hypothyroidism and hyperthyroidism. however, it is unknown whether arachidonic acid metabolites, the potent mediators in cardiovascular system, are involved in cardiovascular disorders caused by hyperthyroidism and hypothyroidism. to answer this question, serum levels of arachidonic acid metabolites in human subjects with hypothyroidism, hyperthyroidism and mice with hypothyroidism or thyroid hormone treatment were determined by a mass spectrometry-based method. over ten arachidonic acid metabolites belonging to three catalytic pathways: cyclooxygenases, lipoxygenases, and cytochrome p450, were quantified simultaneously and displayed characteristic profiles under different thyroid hormone status. the level of 20-hydroxyeicosatetraenoic acid, a cytochrome p450 metabolite, was positively correlated with thyroid hormone level and possibly contributed to the elevated blood pressured in hyperthyroidism. the increased prostanoid (pg) 12 and decreased pge(2) levels in hypothyroid patients might serve to alleviate atherosclerosis associated with dyslipidemia. the elevated level of thromboxane (tx) a(2), as indicated by txb2, in hyperthyroid patients and mice treated with thyroid hormone might bring about pulmonary hypertension frequently found in hyperthyroid patients. in conclusion, our prospective study revealed that arachidonic acid metabolites were differentially affected by thyroid hormone status. certain metabolites may be involved in cardiovascular disorders associated with thyroid diseases. (c) 2015 elsevier inc. all rights reserved. |
| WOS关键词 | PULMONARY-HYPERTENSION ; CARDIOVASCULAR-SYSTEM ; WHICKHAM SURVEY ; NT-PROBNP ; DISEASE ; ATHEROSCLEROSIS ; HYPERTHYROIDISM ; PROSTACYCLIN ; COMMUNITY ; HEALTH |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000356637500002 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376441 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ying, Hao |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Clin Res Ctr, Shanghai 200031, Peoples R China 4.Shanghai Xuhui Cent Hosp, Dept Nutr, Shanghai 200031, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Xuan,Sa, Rina,Ye, Cheng,et al. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach[J]. Prostaglandins & other lipid mediators,2015,118:11-18. |
| APA | Yao, Xuan.,Sa, Rina.,Ye, Cheng.,Zhang, Duo.,Zhang, Shengjie.,...&Ying, Hao.(2015).Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach.Prostaglandins & other lipid mediators,118,11-18. |
| MLA | Yao, Xuan,et al."Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach".Prostaglandins & other lipid mediators 118(2015):11-18. |
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来源：中国科学院大学
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