Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats
文献类型：期刊论文
| 作者 | Xing, Ronge1; He, Xiaofei1,2; Liu, Song1; Yu, Huahua1; Qin, Yukun1; Chen, Xiaolin1; Li, Kecheng1; Li, Rongfeng1; Li, Pengcheng1 |
| 刊名 | Marine drugs
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 13期号:5页码:3072-3090 |
| 关键词 | Differently regioselective chitosan sulfates Hypoglycemic activity Glucose tolerance Plasma insulin Alloxan-induced diabetic rats |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md13053072 |
| 通讯作者 | Xing, ronge(xingronge@qdio.ac.cn) |
| 英文摘要 | The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. the differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-o-sulfochitosan (3-s). the major results are as follows. first, 3,6-di-o-sulfochitosan and 3-o-sulfochitosan exhibited more significant hypoglycemic activities than 2-n-3, 6-di-o-sulfochitosan and 6-o-sulfochitosan. moreover, 3-s-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-o-sulfochitosan. these results indicated that -oso3- at the c3-position of chitosan is a key active site. second, 3-s significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. third, treatment with 3-s significantly increased the plasma insulin levels in the experimental diabetic rats. a noticeable hypoglycemic activity of 3-s in the alloxan-induced diabetic rats was shown. clinical trials are required in the future to confirm the utility of 3-s. |
| WOS关键词 | OXIDATIVE STRESS ; MECHANISM ; TISSUES ; FRUIT |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000356241100026 |
| 出版者 | MDPI AG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376475 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Ronge,He, Xiaofei,Liu, Song,et al. Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats[J]. Marine drugs,2015,13(5):3072-3090. |
| APA | Xing, Ronge.,He, Xiaofei.,Liu, Song.,Yu, Huahua.,Qin, Yukun.,...&Li, Pengcheng.(2015).Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats.Marine drugs,13(5),3072-3090. |
| MLA | Xing, Ronge,et al."Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats".Marine drugs 13.5(2015):3072-3090. |
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来源：中国科学院大学
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