New indole-diterpenoids from the algal-associated fungus aspergillus nidulans
文献类型：期刊论文
| 作者 | Zhang, Peng1,2; Li, Xiao-Ming1; Li, Xin1,2; Wang, Bin-Gui1 |
| 刊名 | Phytochemistry letters
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 12页码:182-185 |
| 关键词 | Indole-diterpenoids Marine algal-derived fungus Polysiphonia scopulorum var. villum Aspergillus nidulans Cytotoxic against brine shrimp Antimicrobial activity |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2015.03.017 |
| 通讯作者 | Wang, bin-gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Two new compounds, including a chlorinated indole-diterpenoid 19-hydroxypenitrem a (1) and its dechlorinated derivative 19-hydroxypenitrem e (2), along with two known congeners (3 and 4), were isolated and identified from the cultures of aspergillus nidulans en-330, an endophytic fungus obtained from the marine red alga polysiphonia scopulorum var. villum. their structures and absolute configurations were assigned on the basis of 1d and 2d nmr and cd experiments. compounds 1-4 exhibited cytotoxic activity against brine shrimp with ld50 values of 3.2, 4.6, 1.7, and 8.7 mu m, respectively. besides, the chlorinated 19-hydroxypenitrem a (1) showed antimicrobial activity against four human-and aqua-pathogens. preliminary sar study revealed that the cl-substitution at c-6 enhanced the cytotoxic activity against brine shrimp and antimicrobial activity, while the 19-oh substitution suppressed the activity. (c) 2015 phytochemical society of europe. published by elsevier b.v. all rights reserved. |
| WOS关键词 | TREMORGENIC MYCO-TOXINS ; PENICILLIUM-CRUSTOSUM ; NODULISPORIC ACID ; PENITREM-A ; BIOSYNTHESIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| WOS类目 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000356336400035 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376503 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Li, Xiao-Ming,Li, Xin,et al. New indole-diterpenoids from the algal-associated fungus aspergillus nidulans[J]. Phytochemistry letters,2015,12:182-185. |
| APA | Zhang, Peng,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2015).New indole-diterpenoids from the algal-associated fungus aspergillus nidulans.Phytochemistry letters,12,182-185. |
| MLA | Zhang, Peng,et al."New indole-diterpenoids from the algal-associated fungus aspergillus nidulans".Phytochemistry letters 12(2015):182-185. |
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来源：中国科学院大学
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