Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans
文献类型：期刊论文
| 作者 | Liang, Xing1,2; Dong, Xintong3; Moerman, Donald G.4; Shen, Kang1,3; Wang, Xiangming1 |
| 刊名 | Developmental cell
 |
| 出版日期 | 2015-05-26 |
| 卷号 | 33期号:4页码:388-400 |
| ISSN号 | 1534-5807 |
| DOI | 10.1016/j.devcel.2015.03.010 |
| 通讯作者 | Shen, kang(kangshen@stanford.edu) |
| 英文摘要 | Sensory dendrites innervate peripheral tissues through cell-cell interactions that are poorly understood. the proprioceptive neuron pvd in c. elegans extends regular terminal dendritic branches between muscle and hypodermis. we found that the pvd branch pattern was instructed by adhesion molecule sax-7/l1cam, which formed regularly spaced stripes on the hypodermal cell. the regularity of the sax-7 pattern originated from the repeated and regularly spaced dense body of the sarcomeres in the muscle. the extracellular proteoglycan unc-52/perlecan linked the dense body to the hemidesmosome on the hypodermal cells, which in turn instructed the sax-7 stripes and pvd dendrites. both unc-52 and hemidesmosome components exhibited highly regular stripes that interdigitated with the sax-7 stripe and pvd dendrites, reflecting the striking precision of subcellular patterning between muscle, hypodermis, and dendrites. hence, the muscular contractile apparatus provides the instructive cues to pattern proprioceptive dendrites. |
| WOS关键词 | CAENORHABDITIS-ELEGANS ; COMPLEX PATTERNS ; UNC-52 GENE ; DROSOPHILA ; ADHESION ; MECHANISMS ; NEURONS ; MECHANOTRANSDUCTION ; MORPHOGENESIS ; ARBORIZATION |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| WOS类目 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000355151900005 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376523 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, Kang |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100101, Peoples R China 3.Stanford Univ, Howard Hughes Med Inst, Dept Biol, Stanford, CA 94305 USA 4.Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z3, Canada |
| 推荐引用方式 GB/T 7714 | Liang, Xing,Dong, Xintong,Moerman, Donald G.,et al. Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans[J]. Developmental cell,2015,33(4):388-400. |
| APA | Liang, Xing,Dong, Xintong,Moerman, Donald G.,Shen, Kang,&Wang, Xiangming.(2015).Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans.Developmental cell,33(4),388-400. |
| MLA | Liang, Xing,et al."Sarcomeres pattern proprioceptive sensory dendritic endings through unc-52/perlecan in c. elegans".Developmental cell 33.4(2015):388-400. |
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来源：中国科学院大学
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