Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction
文献类型：期刊论文
| 作者 | Lee, Sau K.1; Zhang, Wei1,2; Sanderson, Barbara J. S.1 |
| 刊名 | journal of agricultural and food chemistry
 |
| 出版日期 | 2008-08-27 |
| 卷号 | 56期号:16页码:7572-7577 |
| 关键词 | resveratrol chemopreventive cell cycle apoptosis reversible |
| 产权排序 | 2;2 |
| 通讯作者 | sau k.lee |
| 英文摘要 | there is great interest in the potential chemopreventive activity of resveratrol against human cancers. however, there are conflicting results on its growth inhibitory effect on normal cells. this project examined the differential effect of resveratrol at physiologically relevant concentrations on nonmalignant (wil2-ns) and malignant (hl-60) cell lines and compared the underlying mechanisms via cell cycle modulation, apoptosis induction, and genotoxicity potential. twenty-four hours of exposure to resveratrol was toxic to wil2-ns and hl-60 cells in a dose-dependent manner. wil2-ns cells regrew 5 times more than hl-60 cells by 120 h after the removal of 100 mu m resveratrol (p < 0.05). furthermore, significant alterations in cell cycle kinetics were induced by resveratrol in hl-60 cells, but were to a lesser extent for wil2-ns cells. the proportion of apoptosis was also 3 times higher in hl-60 cells as compared to wil2-ns cells for 100 mu m resveratrol (p < 0.05). in conclusion, resveratrol preferentially inhibited the growth of hl-60 cells via cell cycle modulation and apoptosis induction and subsequently directed the cells to irreversible cell death, whereas the effect on wil2-ns cells was largely reversible. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | agriculture, multidisciplinary ; chemistry, applied ; food science & technology |
| 研究领域[WOS] | agriculture ; chemistry ; food science & technology |
| 关键词[WOS] | smooth-muscle-cells ; s-phase ; assay ; mechanisms ; cultures ; grapes ; agent ; block |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000258633700115 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/100807]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Adelaide, SA 5001, Australia 2.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lee, Sau K.,Zhang, Wei,Sanderson, Barbara J. S.. Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction[J]. journal of agricultural and food chemistry,2008,56(16):7572-7577. |
| APA | Lee, Sau K.,Zhang, Wei,&Sanderson, Barbara J. S..(2008).Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction.journal of agricultural and food chemistry,56(16),7572-7577. |
| MLA | Lee, Sau K.,et al."Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction".journal of agricultural and food chemistry 56.16(2008):7572-7577. |
入库方式： OAI收割
来源：大连化学物理研究所
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