The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity
文献类型：期刊论文
| 作者 | Kang, Sining1; Yang, Fan1,2; Li, Lin3; Chen, Huamin4; Chen, She3; Zhang, Jie1 |
| 刊名 | Plant physiology
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 167期号:3页码:1076-+ |
| ISSN号 | 0032-0889 |
| DOI | 10.1104/pp.114.250985 |
| 通讯作者 | Zhang, jie(zhangjie@im.ac.cn) |
| 英文摘要 | Pathogen-associated molecular patterns (pamps) are recognized by plant pattern recognition receptors to activate pamp-triggered immunity (pti). mitogen-activated protein kinases (mapks), as well as other cytoplasmic kinases, integrate upstream immune signals and, in turn, dissect pti signaling via different substrates to regulate defense responses. however, only a few direct substrates of these signaling kinases have been identified. here, we show that pamp perception enhances phosphorylation of brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 (bes1), a transcription factor involved in brassinosteroid (br) signaling pathway, through pathogen-induced mapks in arabidopsis (arabidopsis thaliana). bes1 interacts with mitogen-activated protein kinase6 (mpk6) and is phosphorylated by mpk6. bes1 loss-of-function mutants display compromised resistance to bacterial pathogen pseudomonas syringae pv tomato dc3000. bes1 s286a/s137a double mutation (bes1(ssaa)) impairs pamp-induced phosphorylation and fails to restore bacterial resistance in bes1 mutant, indicating a positive role of bes1 phosphorylation in plant immunity. bes1 is phosphorylated by glycogen synthase kinase3 (gsk3)-like kinase br-insensitive2 (bin2), a negative regulator of br signaling. br perception inhibits bin2 activity, allowing dephosphorylation of bes1 to regulate plant development. however, bes1(ssaa) does not affect br-mediated plant growth, suggesting differential residue requirements for the modulation of bes1 phosphorylation in pti and br signaling. our study identifies bes1 as a unique direct substrate of mpk6 in pti signaling. this finding reveals mapk-mediated bes1 phosphorylation as another bes1 modulation mechanism in plant cell signaling, in addition to gsk3-like kinase-mediated bes1 phosphorylation and f box protein-mediated bes1 degradation. |
| WOS关键词 | PLANT INNATE IMMUNITY ; PSEUDOMONAS-SYRINGAE EFFECTOR ; GENE-EXPRESSION ; SIGNAL-TRANSDUCTION ; TRIGGERED IMMUNITY ; CYTOPLASMIC KINASE ; RECEPTOR FLS2 ; FLAGELLIN ; THALIANA ; DEFENSE |
| WOS研究方向 | Plant Sciences |
| WOS类目 | Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000354413900036 |
| 出版者 | AMER SOC PLANT BIOLOGISTS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376540 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Jie |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Plant Genom, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Biol Sci, Beijing 102206, Peoples R China 4.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kang, Sining,Yang, Fan,Li, Lin,et al. The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity[J]. Plant physiology,2015,167(3):1076-+. |
| APA | Kang, Sining,Yang, Fan,Li, Lin,Chen, Huamin,Chen, She,&Zhang, Jie.(2015).The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity.Plant physiology,167(3),1076-+. |
| MLA | Kang, Sining,et al."The arabidopsis transcription factor brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1 is a direct substrate of mitogen-activated protein kinase6 and regulates immunity".Plant physiology 167.3(2015):1076-+. |
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来源：中国科学院大学
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