Nutritional and regulatory roles of leucine in muscle growth and fat reduction
文献类型：期刊论文
| 作者 | Duan, Yehui1,2; Li, Fengna1; Liu, Hongnan1; Li, Yinghui1,2; Liu, Yingying1,2; Kong, Xiangfeng1; Zhang, Yuzhe1; Deng, Dun1; Tang, Yulong1; Feng, Zemeng1 |
| 刊名 | Frontiers in bioscience-landmark
 |
| 出版日期 | 2015 |
| 卷号 | 20页码:796-813 |
| 关键词 | Leucine Mtor Energy partitioning Ampk Mitochondrial biogenesis Review |
| ISSN号 | 1093-9946 |
| DOI | 10.2741/4338 |
| 通讯作者 | Yin, yulong(yinyulong@isa.ac.cn) |
| 英文摘要 | The metabolic roles for l-leucine, an essential branched-chain amino acid (bcaa), go far beyond serving exclusively as a building block for de novo protein synthesis. growing evidence shows that leucine regulates protein and lipid metabolism in animals. specifically, leucine activates the mammalian target of rapamycin (mtor) signaling pathway, including the 70 kda ribosomal protein s6 kinase 1 (s6k1) and eukaryotic initiation factor (eif) 4e-binding protein 1 (4ebp1) to stimulate protein synthesis in skeletal muscle and adipose tissue and to promote mitochondrial biogenesis, resulting in enhanced cellular respiration and energy partitioning. activation of cellular energy metabolism favors fatty acid oxidation to co2 and water in adipocytes, lean tissue gain in young animals, and alleviation of muscle protein loss in aging adults, lactating mammals, and food-deprived subjects. as a functional amino acid, leucine holds great promise to enhance the growth, efficiency of food utilization, and health of animals and humans. |
| WOS关键词 | CHAIN AMINO-ACIDS ; ACTIVATED PROTEIN-KINASE ; ENDOPLASMIC-RETICULUM STRESS ; MTOR-SIGNALING PATHWAY ; ADIPOSE-TISSUE DEVELOPMENT ; MESSENGER-RNA TRANSLATION ; RAT SKELETAL-MUSCLE ; NEONATAL PIGS ; L-ARGININE ; METABOLIC-REGULATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000354354200014 |
| 出版者 | FRONTIERS IN BIOSCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376546 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yin, Yulong |
| 作者单位 | 1.Chinese Acad Sci, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Hunan Engn & Res Ctr Anim & Poultry Sci,Inst Subt, Key Lab Agroecol Subtrop Reg,Minist Agr,Res Ctr H, Changsha 410125, Hunan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA |
| 推荐引用方式 GB/T 7714 | Duan, Yehui,Li, Fengna,Liu, Hongnan,et al. Nutritional and regulatory roles of leucine in muscle growth and fat reduction[J]. Frontiers in bioscience-landmark,2015,20:796-813. |
| APA | Duan, Yehui.,Li, Fengna.,Liu, Hongnan.,Li, Yinghui.,Liu, Yingying.,...&Yin, Yulong.(2015).Nutritional and regulatory roles of leucine in muscle growth and fat reduction.Frontiers in bioscience-landmark,20,796-813. |
| MLA | Duan, Yehui,et al."Nutritional and regulatory roles of leucine in muscle growth and fat reduction".Frontiers in bioscience-landmark 20(2015):796-813. |
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来源：中国科学院大学
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