Functional characterization of long noncoding rna lnc_bc060912 in human lung carcinoma cells
文献类型：期刊论文
| 作者 | Luo, Huaxia1,2; Sun, Yu1,2; Wei, Guifeng1,2; Luo, Jianjun1; Yang, Xinling1,2,4; Liu, Wei1,2; Guo, Mingzhou5; Chen, Runsheng1,3 |
| 刊名 | Biochemistry
 |
| 出版日期 | 2015-05-12 |
| 卷号 | 54期号:18页码:2895-2902 |
| ISSN号 | 0006-2960 |
| DOI | 10.1021/acs.biochem.5b00259 |
| 通讯作者 | Chen, runsheng(crs@ibp.ac.cn) |
| 英文摘要 | Long noncoding rnas (lncrnas) are pervasively transcribed in the human genome. recent studies suggest that the involvement of incrnas in human diseases could be far more prevalent than previously appreciated. here we have identified a lncrna termed lnc_bc060912 whose expression is increased in human lung and other tumors. lnc_bc060912 is 1.2 kb in length and is composed of two exons. the expression of lncbc060912, was repressed by p53. lnc_bc060912 suppressed cell apoptosis. using a recently developed method for rna-pulldown with formaldehyde cross-linking, we found that lnc_bc060912 interacted with the two dna damage repair proteins parp1 and npm1. together, these results suggest that lnc_bc060912, via parp1 and npm1, affects cell apoptosis and may play important roles in tumorigenesis and cancer progression. |
| WOS关键词 | CHROMATIN ; CANCER ; EXPRESSION ; DISEASE ; PROTEIN ; LANDSCAPE ; EVOLUTION ; CONNECTS ; REVEALS ; COMPLEX |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000354578800011 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376551 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Runsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, CAS Key Lab RNA Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Res Network Computat Biol, Beijing 100101, Peoples R China 4.Hebei North Univ, Coll Lab Med, Zhangjiakou 075000, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Huaxia,Sun, Yu,Wei, Guifeng,et al. Functional characterization of long noncoding rna lnc_bc060912 in human lung carcinoma cells[J]. Biochemistry,2015,54(18):2895-2902. |
| APA | Luo, Huaxia.,Sun, Yu.,Wei, Guifeng.,Luo, Jianjun.,Yang, Xinling.,...&Chen, Runsheng.(2015).Functional characterization of long noncoding rna lnc_bc060912 in human lung carcinoma cells.Biochemistry,54(18),2895-2902. |
| MLA | Luo, Huaxia,et al."Functional characterization of long noncoding rna lnc_bc060912 in human lung carcinoma cells".Biochemistry 54.18(2015):2895-2902. |
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来源：中国科学院大学
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