Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis
文献类型：期刊论文
| 作者 | Lei, X.1; Huang, B.2,3; Li, H.2,3; Jiang, H.4; Hu, X.2,5; Zhang, B.1 |
| 刊名 | Neuroscience
 |
| 出版日期 | 2015-07-23 |
| 卷号 | 299页码:107-124 |
| 关键词 | Network analysis Centrality Anatomical connectivity network Parkinson's disease |
| ISSN号 | 0306-4522 |
| DOI | 10.1016/j.neuroscience.2015.04.056 |
| 通讯作者 | Hu, x.(xthu@mail.kiz.ac.cn) |
| 英文摘要 | Understanding the role of brain regions in anatomical neural networks with parkinson's disease (pd) is essential for improving the clinical protocol or finding new targets for deep brain stimulation (dbs). although numerous changes have been reported in local functional studies, few studies have reported on the anatomical network of the entire brain. here, by developing a series of algorithms, this study provided a whole anatomical neural network of the macaque monkey. then, the drifts in centrality from normal to pd networks were described in terms of complex network analysis and summarized with principal component analysis. results revealed that the areas including the striatum, globus pallidus, amygdala, prefrontal lobe, thalamus, hippocampus, visual cortex, insula, etc., showed relatively notable drifts in their own patterns. the present study also demonstrated that the current targets of dbs shared a common feature: their centrality values being relatively low in the normal brain while intensely drifting with pd. (c) 2015 ibro. published by elsevier ltd. all rights reserved. |
| WOS关键词 | CAUDAL ZONA INCERTA ; SUBTHALAMIC NUCLEUS ; SMALL-WORLD ; STIMULATION ; LEVODOPA ; TREMOR ; CONNECTIVITY ; BETWEENNESS ; DYSKINESIA ; DISORDERS |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355335500011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376572 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hu, X. |
| 作者单位 | 1.Zhejiang Univ, Dept Neurol, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China 2.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mechanisms, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Sichuan Univ, Chengdu 610064, Sichuan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, X.,Huang, B.,Li, H.,et al. Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis[J]. Neuroscience,2015,299:107-124. |
| APA | Lei, X.,Huang, B.,Li, H.,Jiang, H.,Hu, X.,&Zhang, B..(2015).Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis.Neuroscience,299,107-124. |
| MLA | Lei, X.,et al."Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis".Neuroscience 299(2015):107-124. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。