中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis

文献类型:期刊论文

作者Lei, X.1; Huang, B.2,3; Li, H.2,3; Jiang, H.4; Hu, X.2,5; Zhang, B.1
刊名Neuroscience
出版日期2015-07-23
卷号299页码:107-124
关键词Network analysis Centrality Anatomical connectivity network Parkinson's disease
ISSN号0306-4522
DOI10.1016/j.neuroscience.2015.04.056
通讯作者Hu, x.(xthu@mail.kiz.ac.cn)
英文摘要Understanding the role of brain regions in anatomical neural networks with parkinson's disease (pd) is essential for improving the clinical protocol or finding new targets for deep brain stimulation (dbs). although numerous changes have been reported in local functional studies, few studies have reported on the anatomical network of the entire brain. here, by developing a series of algorithms, this study provided a whole anatomical neural network of the macaque monkey. then, the drifts in centrality from normal to pd networks were described in terms of complex network analysis and summarized with principal component analysis. results revealed that the areas including the striatum, globus pallidus, amygdala, prefrontal lobe, thalamus, hippocampus, visual cortex, insula, etc., showed relatively notable drifts in their own patterns. the present study also demonstrated that the current targets of dbs shared a common feature: their centrality values being relatively low in the normal brain while intensely drifting with pd. (c) 2015 ibro. published by elsevier ltd. all rights reserved.
WOS关键词CAUDAL ZONA INCERTA ; SUBTHALAMIC NUCLEUS ; SMALL-WORLD ; STIMULATION ; LEVODOPA ; TREMOR ; CONNECTIVITY ; BETWEENNESS ; DYSKINESIA ; DISORDERS
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
语种英语
WOS记录号WOS:000355335500011
出版者PERGAMON-ELSEVIER SCIENCE LTD
URI标识http://www.irgrid.ac.cn/handle/1471x/2376572
专题中国科学院大学
通讯作者Hu, X.
作者单位1.Zhejiang Univ, Dept Neurol, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
2.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mechanisms, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Sichuan Univ, Chengdu 610064, Sichuan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Kunming 650223, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Lei, X.,Huang, B.,Li, H.,et al. Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis[J]. Neuroscience,2015,299:107-124.
APA Lei, X.,Huang, B.,Li, H.,Jiang, H.,Hu, X.,&Zhang, B..(2015).Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis.Neuroscience,299,107-124.
MLA Lei, X.,et al."Drift in centrality of different brain regions in an anatomical neural network with parkinson's disease: a view from complex network analysis".Neuroscience 299(2015):107-124.

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来源:中国科学院大学

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