Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats
文献类型：期刊论文
| 作者 | Wang, Wen-Fei1; Li, Si-Ming1,2; Ren, Gui-Ping1; Zheng, Wei2; Lu, Yu-Jia2; Yu, Yin-Hang1; Xu, Wen-Juan1; Li, Tian-He3; Zhou, Li-Hong4; Liu, Yan5 |
| 刊名 | Endocrine
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 49期号:1页码:119-129 |
| 关键词 | Obesity Monosodium glutamate Fibroblast growth factor 21 Inflammation Rat |
| ISSN号 | 1355-008X |
| DOI | 10.1007/s12020-014-0433-5 |
| 通讯作者 | Li, de-shan(deshan_li@126.com) |
| 英文摘要 | The aim of this study is to investigate the role of fgf21 in obesity-related inflammation in livers of monosodium glutamate (msg)-induced obesity rats. the msg rats were injected with recombinant murine fibroblast growth factor 21(fgf21) or equal volumes of vehicle. metabolic parameters including body weight, lee's index, food intake, visceral fat and liver weight, intraperitoneal glucose tolerance, glucose, and lipid levels were dynamically measured at specific time points. liver function and routine blood test were also analyzed. further, systemic inflammatory cytokines such as glucose transporter 1 (glut-1), leptin, tnf-alpha, and il-6 mrnas were determined by real-time pcr. fgf21 independently decreased body weight and whole-body fat mass without reducing food intake in the msg rats. fgf21 reduced blood glucose level, lee's index, visceral fat, and liver weight, and improved glucose tolerance, lipid metabolic spectrum, and hepatic steatosis in the msg-obesity rats. liver function parameters including ast, alt, alp, tp, t.bili, and d.bili levels significantly reduced in the fgf21-treated obesity rats compared to the controls. further, fgf21 ameliorated the total and differential white blood cell (wbc) count, serum c-reactive protein (crp), il-6, and tnf-alpha levels in adipose tissues of the obesity rats, suggesting inflammation amelioration in the in the obesity rats by fgf21. fgf21 improves multiple metabolic disorders and ameliorates obesity-related inflammation in the msg-induced obesity rats. |
| WOS关键词 | INSULIN-RESISTANCE ; MOUSE MODEL ; PPAR-ALPHA ; EXPRESSION ; FGF-21 ; FIBROBLAST-GROWTH-FACTOR-21 ; IDENTIFICATION ; REGULATOR ; WEIGHT ; GENES |
| WOS研究方向 | Endocrinology & Metabolism |
| WOS类目 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000355231900014 |
| 出版者 | HUMANA PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376576 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, De-Shan |
| 作者单位 | 1.Northeast Agr Univ, Coll Life Sci, Harbin 150030, Peoples R China 2.Harbin Univ Commerce, Harbin 150028, Peoples R China 3.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 4.Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin 150010, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150010, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wen-Fei,Li, Si-Ming,Ren, Gui-Ping,et al. Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats[J]. Endocrine,2015,49(1):119-129. |
| APA | Wang, Wen-Fei.,Li, Si-Ming.,Ren, Gui-Ping.,Zheng, Wei.,Lu, Yu-Jia.,...&Li, De-Shan.(2015).Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats.Endocrine,49(1),119-129. |
| MLA | Wang, Wen-Fei,et al."Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats".Endocrine 49.1(2015):119-129. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。