New ambuic acid derivatives from the solid culture of pestalotiopsis neglecta and their nitric oxide inhibitory activity
文献类型：期刊论文
| 作者 | Qi, Qiu-Yue1,2; Li, Er-Wei1; Han, Jun-Jie1; Pei, Yun-Fei1; Ma, Ke1; Bao, Li1; Huang, Ying3; Zhao, Feng4; Liu, Hong-Wei1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2015-05-19 |
| 卷号 | 5页码:7 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep09958 |
| 通讯作者 | Liu, hong-wei(liuhw@im.ac.cn) |
| 英文摘要 | Four new ambuic acid derivatives (1-4), and four known derivatives (5-8), were isolated from the solid culture of a plant pathogenic fungus pestalotiopsis neglecta. their structures were elucidated by extensive nmr experiments. the absolute configuration of the c-16 secondary alcohol in 1 was deduced via the cd data of the in situ formed [rh-2(ococf3)(4)] complex with the acetonide derivative of 1. the absolute configuration in 3 was assigned by comparison of the experimental and simulated electronic circular dichroism (ecd) spectrum. the nmr data of compound 5 was reported for the first time. in the nitric oxide (no) inhibition assay, compounds 4, 6 and 7 showed inhibitory activity against the no production in the lipopolysaccharide (lps)-induced macrophage with ic50 values of 88.66, 11.20, and 20.80 mu m, respectively. |
| WOS关键词 | ENDOPHYTIC FUNGUS ; CYCLOHEXENONE ; MICROSPORA ; ACTIVATION ; EPOXIDES ; ALCOHOLS ; CANCER ; TAXOL ; INOS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000355293700001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376577 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Hong-Wei |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China 4.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Qiu-Yue,Li, Er-Wei,Han, Jun-Jie,et al. New ambuic acid derivatives from the solid culture of pestalotiopsis neglecta and their nitric oxide inhibitory activity[J]. Scientific reports,2015,5:7. |
| APA | Qi, Qiu-Yue.,Li, Er-Wei.,Han, Jun-Jie.,Pei, Yun-Fei.,Ma, Ke.,...&Liu, Hong-Wei.(2015).New ambuic acid derivatives from the solid culture of pestalotiopsis neglecta and their nitric oxide inhibitory activity.Scientific reports,5,7. |
| MLA | Qi, Qiu-Yue,et al."New ambuic acid derivatives from the solid culture of pestalotiopsis neglecta and their nitric oxide inhibitory activity".Scientific reports 5(2015):7. |
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来源：中国科学院大学
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