Innate lymphotoxin receptor mediated signaling promotes hsv-1 associated neuroinflammation and viral replication
文献类型：期刊论文
| 作者 | Liang, Yong1,2; Yang, Kaiting1,2; Guo, Jingya1; Wroblewska, Joanna3,4; Fu, Yang-Xin3,4; Peng, Hua1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2015-05-20 |
| 卷号 | 5页码:10 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep10406 |
| 通讯作者 | Fu, yang-xin(yfu@uchicago.edu) |
| 英文摘要 | Host anti-viral innate immunity plays important roles in the defense against hsv-1 infection. in this study, we find an unexpected role for innate lt/light signaling in promoting hsv-1 replication and virus induced inflammation in immunocompromised mice. using a model of footpad hsv-1 infection in rag1-/-mice, we observed that blocking lt/light signaling with lt beta r-ig could significantly delay disease progression and extend the survival of infected mice. lt beta r-ig treatment reduced late proinflammatory cytokine release in the serum and nervous tissue, and inhibited chemokine expression and inflammatory cells infiltration in the dorsal root ganglia (drg). intriguingly, lt beta r-ig treatment restricted hsv-1 replication in the drg but not the footpad. these findings demonstrate a critical role for lt/light signaling in modulating innate inflammation and promoting hsv-1 replication in the nervous system, and suggest a new target for treatment of virus-induced adverse immune response and control of severe hsv-1 infection. |
| WOS关键词 | HERPES-SIMPLEX-VIRUS ; CENTRAL-NERVOUS-SYSTEM ; T-CELL RESPONSES ; SURFACE LYMPHOTOXIN ; LYMPHOID STRUCTURE ; TYPE-1 INFECTION ; TNF SUPERFAMILY ; ENTRY MEDIATOR ; B-CELLS ; LIGHT |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355395300002 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376618 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Fu, Yang-Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA 4.Univ Chicago, Comm Immunol, Chicago, IL 60637 USA |
| 推荐引用方式 GB/T 7714 | Liang, Yong,Yang, Kaiting,Guo, Jingya,et al. Innate lymphotoxin receptor mediated signaling promotes hsv-1 associated neuroinflammation and viral replication[J]. Scientific reports,2015,5:10. |
| APA | Liang, Yong,Yang, Kaiting,Guo, Jingya,Wroblewska, Joanna,Fu, Yang-Xin,&Peng, Hua.(2015).Innate lymphotoxin receptor mediated signaling promotes hsv-1 associated neuroinflammation and viral replication.Scientific reports,5,10. |
| MLA | Liang, Yong,et al."Innate lymphotoxin receptor mediated signaling promotes hsv-1 associated neuroinflammation and viral replication".Scientific reports 5(2015):10. |
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来源：中国科学院大学
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