Cellular microrna mir-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity
文献类型：期刊论文
| 作者 | Jia, Xiaojuan1,2,3; Bi, Yuhai3; Li, Jing3; Xie, Qing5; Yang, Hanchun1,2; Liu, Wenjun3,4 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2015-05-27 |
| 卷号 | 5页码:14 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep10651 |
| 通讯作者 | Liu, wenjun(liuwj@im.ac.cn) |
| 英文摘要 | Porcine reproductive and respiratory syndrome (prrs) has caused large economic losses in the swine industry in recent years. current prrs vaccines fail to effectively prevent and control this disease. consequently, there is a need to develop new antiviral strategies. micrornas play critical roles in intricate host-pathogen interaction networks, but the involvement of mirnas during prrs virus (prrsv) infection is not well understood. in this study, pretreatment with mir-26a induced a significant inhibition of prrsv replication and remission of the cytopathic effect in marc-145 cells, and this antiviral effect was sustained for at least 120 h. luciferase reporter analysis showed that the prrsv genome was not the target of mirna-26a. instead, rna-seq analysis demonstrated that mir-26a significantly up-regulated innate anti-viral responses, including activating the type i interferon (ifn) signaling pathway and promoting the production of ifn-stimulated genes. these findings suggest that delivery of mir-26a may provide a potential strategy for anti-prrsv therapies. |
| WOS关键词 | INFLUENZA-A VIRUSES ; MARC-145 CELLS ; ALVEOLAR MACROPHAGES ; TRANSCRIPTION FACTOR ; INTERFERING RNAS ; EXPRESSION ; INHIBITION ; PRRSV ; EZH2 ; IDENTIFICATION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355542200001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376631 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Wenjun |
| 作者单位 | 1.China Agr Univ, Coll Vet Med, Minist Agr, Key Lab Anim Epidemiol & Zoonosis, Beijing 100193, Peoples R China 2.China Agr Univ, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100101, Peoples R China 5.Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Xiaojuan,Bi, Yuhai,Li, Jing,et al. Cellular microrna mir-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity[J]. Scientific reports,2015,5:14. |
| APA | Jia, Xiaojuan,Bi, Yuhai,Li, Jing,Xie, Qing,Yang, Hanchun,&Liu, Wenjun.(2015).Cellular microrna mir-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity.Scientific reports,5,14. |
| MLA | Jia, Xiaojuan,et al."Cellular microrna mir-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity".Scientific reports 5(2015):14. |
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来源：中国科学院大学
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