Tunneling nanotubes between rat primary astrocytes and c6 glioma cells alter proliferation potential of glioma cells
文献类型：期刊论文
| 作者 | Zhang, Lei; Zhang, Yan |
| 刊名 | Neuroscience bulletin
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 31期号:3页码:371-378 |
| 关键词 | Tunneling nanotube Astrocyte Glioma Proliferation P53 |
| ISSN号 | 1673-7067 |
| DOI | 10.1007/s12264-014-1522-4 |
| 通讯作者 | Zhang, yan(yanzhang@pku.edu.cn) |
| 英文摘要 | The tunneling nanotube (tnt) is a newly discovered, long and thin tubular structure between cells. in this study, we established a co-culture system for rat primary astrocytes and c6 glioma cells and found that tnts formed between them. most of the tnts initiated from astrocytes towards c6 glioma cells. the formation of tnts depended on p53. in addition, hydrogen peroxide increased the number of tnts in the co-culture system. established tnts reduced the proliferation of c6 glioma cells. our data suggest that tnts between astrocytes and glioma cells facilitate substance transfer and therefore alter the properties, including the proliferation potential, of glioma cells. |
| WOS关键词 | MEMBRANE NANOTUBES ; IMMUNE CELLS ; ANIMAL-CELLS ; STEM-CELLS ; T-CELLS ; COMMUNICATION ; CONNECTIONS ; CANCER ; TUMORS ; ROUTE |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355619700011 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376632 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Yan |
| 作者单位 | Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Zhang, Yan. Tunneling nanotubes between rat primary astrocytes and c6 glioma cells alter proliferation potential of glioma cells[J]. Neuroscience bulletin,2015,31(3):371-378. |
| APA | Zhang, Lei,&Zhang, Yan.(2015).Tunneling nanotubes between rat primary astrocytes and c6 glioma cells alter proliferation potential of glioma cells.Neuroscience bulletin,31(3),371-378. |
| MLA | Zhang, Lei,et al."Tunneling nanotubes between rat primary astrocytes and c6 glioma cells alter proliferation potential of glioma cells".Neuroscience bulletin 31.3(2015):371-378. |
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来源：中国科学院大学
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