C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of notch2 signalling
文献类型：期刊论文
| 作者 | Zhu, Pingping1,2; Wang, Yanying2; Du, Ying2; He, Lei3; Huang, Guanling2; Zhang, Geng2; Yan, Xinlong2; Fan, Zusen2 |
| 刊名 | Nature communications
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 6页码:13 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms8122 |
| 通讯作者 | Fan, zusen(fanz@moon.ibp.ac.cn) |
| 英文摘要 | Liver cancer stem cells (cscs) harbour self-renewal and differentiation properties, accounting for chemotherapy resistance and recurrence. however, the molecular mechanisms to sustain liver cscs remain largely unknown. in this study, based on analysis of several hepatocellular carcinoma (hcc) transcriptome datasets and our experimental data, we find that c8orf4 is weakly expressed in hcc tumours and liver cscs. c8orf4 attenuates the self-renewal capacity of liver cscs and tumour propagation. we show that notch2 is activated in liver cscs. c8orf4 is located in the cytoplasm of hcc tumour cells and associates with the notch2 intracellular domain, which impedes the nuclear translocation of n2icd. c8orf4 deletion causes the nuclear translocation of n2icd that triggers the notch2 signalling, which sustains the stemness of liver cscs. finally, notch2 activation levels are consistent with clinical severity and prognosis of hcc patients. altogether, c8orf4 negatively regulates the self-renewal of liver cscs via suppression of notch2 signalling. |
| WOS关键词 | TUMOR-INITIATING CELLS ; HEPATOCELLULAR-CARCINOMA ; THYROID-CANCER ; BREAST-CANCER ; GENE ; PATHWAY ; IDENTIFICATION ; INTEGRATION ; COMMITMENT ; PREDICTION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355533000010 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376650 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Fan, Zusen |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun CAS, Beijing 100101, Peoples R China 3.Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, Beijing 100853, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Pingping,Wang, Yanying,Du, Ying,et al. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of notch2 signalling[J]. Nature communications,2015,6:13. |
| APA | Zhu, Pingping.,Wang, Yanying.,Du, Ying.,He, Lei.,Huang, Guanling.,...&Fan, Zusen.(2015).C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of notch2 signalling.Nature communications,6,13. |
| MLA | Zhu, Pingping,et al."C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of notch2 signalling".Nature communications 6(2015):13. |
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来源：中国科学院大学
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