Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression
文献类型：期刊论文
| 作者 | Xu, Yi1; Chang, Renxu1; Peng, Zhiyong2,3; Wang, Yanmei1; Ji, Weiwei1; Guo, Jingyu1; Song, Lele1; Dai, Cheng1; Wei, Wei1; Wu, Yanjun1 |
| 刊名 | Nature communications
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 6页码:12 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms8184 |
| 通讯作者 | Zhan, lixing(lxzhan@sibs.ac.cn) |
| 英文摘要 | Pancreatic cancer (pc) is a particularly lethal form of cancer with high potential for metastasis to distant organs. disruption of cell polarity is a hallmark of advanced epithelial tumours. here we show that the polarity protein af6 (afadin and mllt4) is expressed at low levels in pc. we demonstrate that depletion of af6 markedly promotes proliferation and metastasis of pc cells through upregulation of the expression of snail protein, and this requires the nuclear localization of af6. furthermore, af6 deficiency in pc cells leads to increased formation of a dishevelled 2 (dvl2)-foxe1 complex on the promoter region of snail gene, and activation of snail expression. altogether, our data established af6 as a potential inhibitor of metastasis in pc cells. targeting the dvl2-foxe1-snail signalling axis may thus represent a promising therapeutic strategy. |
| WOS关键词 | CELL-CELL JUNCTIONS ; BREAST-CANCER ; ADHERENS JUNCTION ; BETA-CATENIN ; PDZ DOMAIN ; RAS ; AFADIN ; GENE ; MIGRATION ; MLL-AF6 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355536900003 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376675 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhan, Lixing |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghaim 200031, Peoples R China 2.Second Mil Med Univ, Changhai Hosp, Dept Pancreat Surg, Shanghai 200433, Peoples R China 3.Second Mil Med Univ, Navy Med Res Inst, Shanghai 200433, Peoples R China 4.Tongji Univ, Sch Med, Shanghai Peoples Hosp 2, Dept Gastroenterol, Shanghai 200011, Peoples R China 5.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yi,Chang, Renxu,Peng, Zhiyong,et al. Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression[J]. Nature communications,2015,6:12. |
| APA | Xu, Yi.,Chang, Renxu.,Peng, Zhiyong.,Wang, Yanmei.,Ji, Weiwei.,...&Zhan, Lixing.(2015).Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression.Nature communications,6,12. |
| MLA | Xu, Yi,et al."Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression".Nature communications 6(2015):12. |
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来源：中国科学院大学
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