Human respiratory syncytial virus infection is inhibited by ifn-induced transmembrane proteins
文献类型：期刊论文
| 作者 | Zhang, Wei1,2; Zhang, Lei1; Zan, Yanlu1; Du, Ning1,2; Yang, Yang1,2; Tien, Po1 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2015 |
| 卷号 | 96页码:170-182 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/vir.0.066555-0 |
| 通讯作者 | Tien, po(tienpo@sun.im.ac.cn) |
| 英文摘要 | The ifn immune system plays an essential role in protecting the host against most viral infections. in order to explore the interactions between the ifn pathway and human respiratory syncytial virus.(rsv) infection, and to identify potential ifn-stimulated genes (isgs) that may be involved in suppressing the replication of rsv, we utilized an ifn pathway-specific microarray to study the effects of rsv infection on the ifn pathway in hela cells. we showed that rsv infection enhanced the expression of a series of isgs, including oligoadenylate synthetase 2, ifitm1 (ifn-induced transmembrane protein 1) and myxovirus resistance 2. our results also showed that the ifitm proteins potently inhibited rsv infection mainly by interfering with both virus entry and the subsequent replication steps, but not the attachment process. the antiviral effect of ifitm3 was not affected by ubiquitination modification. furthermore, knocking down the endogenous and ifn-induced expression of ifitm1 and 3 facilitated rsv infection. expression of the ifitm proteins was found to delay the phosphorylation of ifn regulatory factor 3 through interfering with the detection of viral rna by mda5 (melanoma differentiation-associated gene 5) and rig-i (retinoic acid-inducible gene these results demonstrated that the restriction of rsv infection by the ifitm proteins was achieved through the inhibition of virus entry and replication, and they provided further insight for exploring the mechanism of ifitm-protein-mediated virus restriction. |
| WOS关键词 | IFITM PROTEINS ; INTERFERON ; REPLICATION ; RESISTANCE |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000355784600020 |
| 出版者 | SOC GENERAL MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376731 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tien, Po |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Ctr Mol Virol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wei,Zhang, Lei,Zan, Yanlu,et al. Human respiratory syncytial virus infection is inhibited by ifn-induced transmembrane proteins[J]. Journal of general virology,2015,96:170-182. |
| APA | Zhang, Wei,Zhang, Lei,Zan, Yanlu,Du, Ning,Yang, Yang,&Tien, Po.(2015).Human respiratory syncytial virus infection is inhibited by ifn-induced transmembrane proteins.Journal of general virology,96,170-182. |
| MLA | Zhang, Wei,et al."Human respiratory syncytial virus infection is inhibited by ifn-induced transmembrane proteins".Journal of general virology 96(2015):170-182. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。