Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome p450s in zebrafish (danio rerio)
文献类型：期刊论文
| 作者 | Du, Miaomiao1,2; Fang, Chao1,2; Qiu, Ling1; Bong, Sijun1; Zhang, Xian1; Yan, Changzhou1 |
| 刊名 | Chemosphere
 |
| 出版日期 | 2015-08-01 |
| 卷号 | 132页码:24-31 |
| 关键词 | Hexabromocyclododecane Diastereoisomer Aryl hydrocarbon receptor Cytochrome p450 |
| ISSN号 | 0045-6535 |
| DOI | 10.1016/j.chemosphere.2015.02.049 |
| 通讯作者 | Zhang, xian(xzhang@iue.ac.cn) |
| 英文摘要 | In order to elucidate the mechanism for diastereoisomer-specific toxicity and metabolism of hexabromo-cyclododecanes (hbcds) in biota, zebrafish (danio rerio) were exposed to different concentrations of individual hbcd diastereoisomers (alpha-, beta- and gamma-hbcd) in water for 7 and 21 d. we examined the gene expression of aryl hydrocarbon receptor (ahr) and cytochrome p450 (cyp), as well as ethoxyresorufin-o-deethylase (erod) activity in zebrafish livers. exposure to different hbcd diastereoisomers caused different expression of ahrs in zebrafish livers. for instance, 10 and 100 mu g l-1 of alpha- and beta-hbcd up-regulated the expressions of ahr1a and ahr1b in zebrafish liver, whereas 10 and 100 mu g l-1 of gamma-hbcd down-regulated them after 7 d exposure. alpha-hbcd showed the most significant up-regulation of ahr1a and ahr1b expression, whereas gamma-hbcd showed the most significant down-regulation of their expression among three hbcd diastereoisomers. moreover, hbcds could affect the expression of cyp15 as well as erod activity in a gene-specific and diastereoisomer-specific manner. alpha-, beta- and gamma-hbcd inhibited cyp1a expression but enhanced the expression of cyp1b1 and cyp1c1. alpha-, beta- and gamma-hbcd showed different degrees of effect on the same cyp1 gene in a concentration-dependent way. the different effects of hbcd diastereoisomers on these genes we examined and erod activity not only indicate diastereoisomer-specific toxic effect, but also in turn explain diastereoisomer-specific accumulation of hbcds in zebrafish. (c) 2015 published by elsevier ltd. |
| WOS关键词 | BROMINATED FLAME RETARDANTS ; ENANTIOMER-SPECIFIC ACCUMULATION ; JUVENILE RAINBOW-TROUT ; TETRABROMOBISPHENOL-A ; GENE-EXPRESSION ; DEVELOPMENTAL TOXICITY ; ENZYMES ; CELL ; INDUCTION ; ENVIRONMENT |
| WOS研究方向 | Environmental Sciences & Ecology |
| WOS类目 | Environmental Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355882900004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376759 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Xian |
| 作者单位 | 1.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Miaomiao,Fang, Chao,Qiu, Ling,et al. Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome p450s in zebrafish (danio rerio)[J]. Chemosphere,2015,132:24-31. |
| APA | Du, Miaomiao,Fang, Chao,Qiu, Ling,Bong, Sijun,Zhang, Xian,&Yan, Changzhou.(2015).Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome p450s in zebrafish (danio rerio).Chemosphere,132,24-31. |
| MLA | Du, Miaomiao,et al."Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome p450s in zebrafish (danio rerio)".Chemosphere 132(2015):24-31. |
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来源：中国科学院大学
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