Protein kinase c delta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation
文献类型：期刊论文
| 作者 | Zhao, KW; Li, X; Zhao, Q; Huang, Y; Li, D; Peng, ZG; Shen, WZ; Zhao, J; Zhou, QS; Chen, Z |
| 刊名 | Blood
 |
| 出版日期 | 2004-12-01 |
| 卷号 | 104期号:12页码:3731-3738 |
| ISSN号 | 0006-4971 |
| 通讯作者 | Chen, gq() |
| 英文摘要 | Although phospholipid scramblase 1 (plscr1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. in this report, we investigate the potential role of plscr1 in leukemic cell differentiation. we show that all-trans retinoic acid (atra), an effective differentiation-inducing agent of acute promyelocytic leukemic (apl) cells, can elevate plscr1 expression in atra-sensitive apl cells nb4 and hl60, but not in maturation-resistant nb4-lr1 cells. atra- and phorbol 12-myristate 13-acetate (pma)-induced monocytic differentiation is accompanied by increased plscr1 expression, whereas only a slight or no elevation of plscr1 expression is observed in u937 cells differentiated with dimethyl sulfoxide (dmso), sodium butyrate, or vitamin d3. cell differentiation with atra and pma, but not with vitamin d3 or dmso, results in phosphorylation of protein kinase cdelta (pkcdelta), and the pkcdelta-specific inhibitor rottlerin nearly eliminates the atra- and pma-induced expression of plscr1, while ectopic expression of a constitutively active form of pkcdelta directly increases plscr1 expression. finally, decreasing plscr1 expression with small interfering rna inhibits atra/pma-induced differentiation. taken together, these results suggest that as a protein induced upon pkcdelta activation, plscr1 is required for atra- and pma-triggered leukemic cell differentiation. (c) 2004 by the american society of hematology. |
| WOS关键词 | ACUTE PROMYELOCYTIC LEUKEMIA ; GROWTH-FACTOR RECEPTOR ; PLASMA-MEMBRANE ; MYELOID-LEUKEMIA ; TRANSBILAYER MOVEMENT ; INTERFERON-ALPHA ; CANCER-THERAPY ; U937 CELLS ; PKC-DELTA ; APOPTOSIS |
| WOS研究方向 | Hematology |
| WOS类目 | Hematology |
| 语种 | 英语 |
| 出版者 | AMER SOC HEMATOLOGY |
| WOS记录号 | WOS:000225351600053 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376789 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, GQ |
| 作者单位 | 1.Shanghai Med Univ 2, Hlth Sci Ctr, Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 3.SSMU, Rui Jin Hosp, Inst Hematol, Shanghai, Peoples R China 4.SSMU, Shanghai Terry Fox Canc Ctr, Dept Pathophysiol, Shanghai, Peoples R China 5.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA |
| 推荐引用方式 GB/T 7714 | Zhao, KW,Li, X,Zhao, Q,et al. Protein kinase c delta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation[J]. Blood,2004,104(12):3731-3738. |
| APA | Zhao, KW.,Li, X.,Zhao, Q.,Huang, Y.,Li, D.,...&Chen, GQ.(2004).Protein kinase c delta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.Blood,104(12),3731-3738. |
| MLA | Zhao, KW,et al."Protein kinase c delta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation".Blood 104.12(2004):3731-3738. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。