Identification and characterization of gh receptor and serum gh-binding protein in chinese sturgeon (acipenser sinensis)
文献类型：期刊论文
| 作者 | Liao, ZY; Zhu, SQ |
| 刊名 | Acta biochimica et biophysica sinica
 |
| 出版日期 | 2004-12-01 |
| 卷号 | 36期号:12页码:811-816 |
| 关键词 | Chinese sturgeon Growth hormone receptor Growth hormone binding protein Ligand binding |
| ISSN号 | 1672-9145 |
| 通讯作者 | Zhu, sq() |
| 英文摘要 | Chinese sturgeon, a kind of cartilage ganoid, has a history of over one billion years and it is called the living fossil of aquatic biology since it keeps some evolutionary trace. here, we characterized the growth hormone receptor (ghr) and serum growth hormone binding protein (ghbp) of chinese sturgeon. it was shown that ghr was expressed in various tissues, mainly in hepatic, kidney and intestine tissues. ghr on the hepatic membrane has high and specific affinity for bream gh (brgh) and scatchard analysis of the binding data showed a single class of high affinity binding site with an association constant k-a of 3.1 x 10(9) m-1. a specific band around 94 kd was detected by sds-page in cross-linking studies of membrane receptors. after incubation of chinese sturgeon serum with i-125-brgh, a i-125-brgh-ghbp complex was identified by sephadex g-75, indicating that in the serum exists ghbp specially binding to brgh. |
| WOS关键词 | GROWTH-HORMONE RECEPTOR ; SIGNAL-TRANSDUCTION ; LIVER |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000225986000005 |
| 出版者 | SHANGHAI INST BIOCHEMISTRY, ACADEMIA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376855 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, SQ |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Proteom Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, ZY,Zhu, SQ. Identification and characterization of gh receptor and serum gh-binding protein in chinese sturgeon (acipenser sinensis)[J]. Acta biochimica et biophysica sinica,2004,36(12):811-816. |
| APA | Liao, ZY,&Zhu, SQ.(2004).Identification and characterization of gh receptor and serum gh-binding protein in chinese sturgeon (acipenser sinensis).Acta biochimica et biophysica sinica,36(12),811-816. |
| MLA | Liao, ZY,et al."Identification and characterization of gh receptor and serum gh-binding protein in chinese sturgeon (acipenser sinensis)".Acta biochimica et biophysica sinica 36.12(2004):811-816. |
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来源：中国科学院大学
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