Weight reduction by chinese medicinal herbs may be related to inhibition of fatty acid synthase
文献类型：期刊论文
| 作者 | Tian, WX; Li, LC; Wu, XD; Chen, CC |
| 刊名 | Life sciences
 |
| 出版日期 | 2004-03-26 |
| 卷号 | 74期号:19页码:2389-2399 |
| 关键词 | Weight reduction Chinese medicinal herb Fatty acid synthase Inhibition |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2003.09.064 |
| 通讯作者 | Tian, wx(tianweixi@gscas.ac.cn) |
| 英文摘要 | Fatty acid synthase (ec 2. 3. 1. 85, abbr. fas) is reported as a potential new therapeutic target for the treatment of obesity. thirty one chinese medicinal herbs used in weight reducing prescriptions of traditional chinese medicine (tcm) were investigated for fas inhibition. it was found that 17 of these herbs exhibited fas inhibitor activity, and 9 were highly potent fas inhibitors. the inhibitory potencies of the active components of tuber fleeceflower root, parasitic loranthus, green tea leaf and ginkgo leaf were similar to or greater than cerulenin and c75. the first three of these four herbs significantly reduced body weight of rats upon their oral incubation. moreover, tuber fleeceflower root and parasitic loranthus significantly reduced food intake in rats. these results indicate that many of weight reducing herbs used in tcm do so by inhibiting fas. they also hold promise for the development of new nontoxic and low cost weight reducing substances from these herbs. (c) 2004 elsevier inc. all rights reserved. |
| WOS关键词 | ANTIBIOTIC CERULENIN ; SYNTHETASE ; ENZYME ; HEALTH |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000220129300004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376918 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tian, WX |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Dept Biol, Beijing 100039, Peoples R China 2.Chinese Tradit Med Inst China, Beijing 100700, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, WX,Li, LC,Wu, XD,et al. Weight reduction by chinese medicinal herbs may be related to inhibition of fatty acid synthase[J]. Life sciences,2004,74(19):2389-2399. |
| APA | Tian, WX,Li, LC,Wu, XD,&Chen, CC.(2004).Weight reduction by chinese medicinal herbs may be related to inhibition of fatty acid synthase.Life sciences,74(19),2389-2399. |
| MLA | Tian, WX,et al."Weight reduction by chinese medicinal herbs may be related to inhibition of fatty acid synthase".Life sciences 74.19(2004):2389-2399. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。