A novel domain-based method for predicting the functional classes of proteins
文献类型：期刊论文
| 作者 | Yu, XJ; Lin, JC; Shi, TL; Li, YX |
| 刊名 | Chinese science bulletin
 |
| 出版日期 | 2004-11-01 |
| 卷号 | 49期号:22页码:2379-2384 |
| 关键词 | Protein function prediction Maximum likelihood estimation Expectation maximization Domain |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/982004-142 |
| 通讯作者 | Li, yx() |
| 英文摘要 | Prediction of protein functions from known genomic sequences is an important mission of bioinformatics. one approach is to classify proteins into functional categories. we have therefore developed a method based on protein domain composition and the maximum likelihood estimation (mle) algorithm to classify proteins according to functions. using the saccharomyces cerevisiae genome, we compared the effectiveness of the mle approach with that of an intuitive and simple method. the mle method outperformed the simple method, achieving an estimated specificity of 75.45% and an estimated sensitivity of 40.26%. these results indicate that domain is an important feature of proteins and is closely related to protein function. |
| WOS关键词 | SEQUENCE ; GENOMES ; GENES ; CLASSIFICATION ; ALGORITHM ; PROFILES ; DATABASE ; PFAM |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000226823300008 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376931 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, YX |
| 作者单位 | Chinese Acad Sci, Grad Sch, Bioinformat Ctr, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, XJ,Lin, JC,Shi, TL,et al. A novel domain-based method for predicting the functional classes of proteins[J]. Chinese science bulletin,2004,49(22):2379-2384. |
| APA | Yu, XJ,Lin, JC,Shi, TL,&Li, YX.(2004).A novel domain-based method for predicting the functional classes of proteins.Chinese science bulletin,49(22),2379-2384. |
| MLA | Yu, XJ,et al."A novel domain-based method for predicting the functional classes of proteins".Chinese science bulletin 49.22(2004):2379-2384. |
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来源：中国科学院大学
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