Fabrication, characterization, and in vitro degradation of composite scaffolds based on phbv and bioactive glass
文献类型：期刊论文
| 作者 | Li, HY; Du, RL; Chang, J |
| 刊名 | Journal of biomaterials applications
 |
| 出版日期 | 2005-10-01 |
| 卷号 | 20期号:2页码:137-155 |
| 关键词 | Phbv Bioactive glass Porous composite scaffold Bioactivity Degradation |
| ISSN号 | 0885-3282 |
| DOI | 10.1177/0885328205049472 |
| 通讯作者 | Chang, j() |
| 英文摘要 | Composite scaffolds of polyhydroxybutyrate-polyhydroxyvalerate (phbv) with sol-gel-derived bioactive glass (bg, 58s) are fabricated by compression molding, thermal processing, and salt particulate leaching method. structure and mechanical properties of the scaffolds are determined. the bioactivity of the composites is evaluated by soaking the scaffolds in a simulated body fluid (sbf), and the formation of the apatite layer on the scaffolds is determined by scanning electron microscopy (sem) and energy-dispersive spectrometry (eds). the results show that the phbv/bg composites are bioactive as they induce the formation of apatite on the composite scaffolds after soaking in sbf for 3 days. in addition, the measurements of the water contact angles suggest that incorporation of bg into phbv can improve the hydrophilicity of the composites and the enhancement is dependent on the bg content. furthermore, the degradation assessment of the scaffolds is performed in phosphate-buffered saline (pbs) solution at 37 degrees c. weight loss and water absorption of the scaffolds, ph of the incubation media, and molecular weight measurements of the phbv in the scaffolds are used to monitor the degradation of the scaffolds during a nine-week incubation in pbs. it has been found that the incorporation of bioactive glass into the phbv delayed the degradation of phbv in the composite scaffolds for the period investigated. the present results show not only a useful method to prepare composite scaffolds with improved properties but also a way of adjusting the in vitro degradation behavior of composite scaffolds by tailoring the content of bioactive glass. |
| WOS关键词 | TISSUE ENGINEERING APPLICATIONS ; BONE TISSUE ; SURFACE MODIFICATION ; POLYLACTIDE FOAMS ; VIVO DEGRADATION ; POLYMER ; ACID) ; PROLIFERATION ; BIOGLASS(R) ; OSTEOBLASTS |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000232398600003 |
| 出版者 | SAGE PUBLICATIONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377016 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chang, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, HY,Du, RL,Chang, J. Fabrication, characterization, and in vitro degradation of composite scaffolds based on phbv and bioactive glass[J]. Journal of biomaterials applications,2005,20(2):137-155. |
| APA | Li, HY,Du, RL,&Chang, J.(2005).Fabrication, characterization, and in vitro degradation of composite scaffolds based on phbv and bioactive glass.Journal of biomaterials applications,20(2),137-155. |
| MLA | Li, HY,et al."Fabrication, characterization, and in vitro degradation of composite scaffolds based on phbv and bioactive glass".Journal of biomaterials applications 20.2(2005):137-155. |
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来源：中国科学院大学
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