Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration
文献类型：期刊论文
| 作者 | Du, YT; Wang, X; Wu, XD; Tian, WX |
| 刊名 | Journal of enzyme inhibition and medicinal chemistry
 |
| 出版日期 | 2005-08-01 |
| 卷号 | 20期号:4页码:349-356 |
| 关键词 | Inhibitor Fatty acid synthase Black tea Theaflavins Body weight Food intake |
| ISSN号 | 1475-6366 |
| DOI | 10.1080/14756360500148841 |
| 通讯作者 | Tian, wx(tianweixi@gscas.ac.cn) |
| 英文摘要 | The inhibitory effects of a black tea extract on fatty acid synthase were measured through inhibition kinetics. the keemun black tea extract showed more potent inhibitory activity on fatty acid synthase than green tea extract. additionally, the inhibitory ability of the black tea extract depended on the extracting solvent and the conditions used. only 10-23% of the inhibitory activity from the black tea was extracted by the general method of boiling with water. the results suggested that the main fatty acid synthase inhibitors in black tea might be theaflavins. which were more potent than epigallocatechin gallate or c75. the reaction site on the fatty acid synthase and the inhibition kinetics for the extract were different from those of epigallocatechin gallate or c75. in addition, keemun black tea extract significantly reduced food intake, body weight and blood triglyceride of diet-induced obesity sd rats via oral administration. |
| WOS关键词 | HIGH BLOOD CHOLESTEROL ; GREEN TEA ; EPIGALLOCATECHIN GALLATE ; EXPERT PANEL ; OBESITY ; ADULTS ; CHEMISTRY ; RISK |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000231960400006 |
| 出版者 | INFORMA HEALTHCARE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377034 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tian, WX |
| 作者单位 | Chinese Acad Sci, Dept Biol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, YT,Wang, X,Wu, XD,et al. Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration[J]. Journal of enzyme inhibition and medicinal chemistry,2005,20(4):349-356. |
| APA | Du, YT,Wang, X,Wu, XD,&Tian, WX.(2005).Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration.Journal of enzyme inhibition and medicinal chemistry,20(4),349-356. |
| MLA | Du, YT,et al."Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration".Journal of enzyme inhibition and medicinal chemistry 20.4(2005):349-356. |
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来源：中国科学院大学
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