The effect of bicuculline and strychnine on the latency of neuron in inferior colliculus and auditory cortex of balb/c mouse
文献类型：期刊论文
| 作者 | Zhang, J; Qiu, Q; Tang, J; Xiao, ZJ; Shen, JX |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2005-11-01 |
| 卷号 | 32期号:11页码:1055-1060 |
| 关键词 | Auditory neuron Latency Characteristic frequency Intensity Bicuculline Strychnine |
| ISSN号 | 1000-3282 |
| 通讯作者 | Shen, jx() |
| 英文摘要 | Frequency and intensity are two of the important parameters of sounds. many researchers use spike rate of auditory neurons to represent the two parameters generally. some studies showed that response latency may represent frequency and intensity too. however, it is not clear where the two parameters are encoded by response latency in the auditory pathway. gaba and glycine are two ubiquitous inhibitory neurotransmitters. iontophoretically bicuculline (antagonist to gaba-a) or strychnine (antagonist to glycine) was injected to observe the change of response latency. if the relationship between response latency and intensity or frequency has changed, sound may be encoded locally. if the relationship keeps unchanged, this information may be transferred from the inferior nervous centres. the auditory neurons in the inferior colliculus and al area of auditory cortex of balb/c mouse were studied. the results show that the relationship between response latency and intensity or frequency didn't change after the application of bicuculline or strychnine. it suggests that the encoding relationship between response latency and intensity or frequency didn't be completed in the inferior colliculus or al area of auditory cortex, but it is probably transferred from the inferior nervous centres. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000233534300009 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377110 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, JX |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.So Med Univ, Basic Med Sch, Guangzhou 510515, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, J,Qiu, Q,Tang, J,et al. The effect of bicuculline and strychnine on the latency of neuron in inferior colliculus and auditory cortex of balb/c mouse[J]. Progress in biochemistry and biophysics,2005,32(11):1055-1060. |
| APA | Zhang, J,Qiu, Q,Tang, J,Xiao, ZJ,&Shen, JX.(2005).The effect of bicuculline and strychnine on the latency of neuron in inferior colliculus and auditory cortex of balb/c mouse.Progress in biochemistry and biophysics,32(11),1055-1060. |
| MLA | Zhang, J,et al."The effect of bicuculline and strychnine on the latency of neuron in inferior colliculus and auditory cortex of balb/c mouse".Progress in biochemistry and biophysics 32.11(2005):1055-1060. |
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来源：中国科学院大学
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