Functional gaba(b) receptors are expressed at the cone photoreceptor terminals in bullfrog retina
文献类型：期刊论文
| 作者 | Liu, J; Zhao, JW; Du, JL; Yang, XL |
| 刊名 | Neuroscience
 |
| 出版日期 | 2005 |
| 卷号 | 132期号:1页码:103-113 |
| 关键词 | Gaba Calcium channel Barium current Transmitter release Horizontal cell |
| ISSN号 | 0306-4522 |
| DOI | 10.1016/j.neuroscience.2004.12.024 |
| 通讯作者 | Yang, xl() |
| 英文摘要 | Gaba(b) receptors at the cone terminals in bullfrog retina were characterized by immunocytochemical and whole-cell patch clamp techniques in retinal slice preparations. somata, axons and synaptic terminals (pedicles) of cones were both gabab receptor (gaba(b)r) 1 and gaba(b)r2 immunoreactive. physiologically, barium/calcium currents of cones to voltage steps were significantly reduced in size when gaba was puffed to cone terminals in the presence of picrotoxin that is supposed to block both gaba(a) and gaba(c) receptors. similar reduction in barium currents was obtained with puff application of baclofen to cone terminals. these results suggest the presence of functional gaba(b) receptors at the bullfrog cone terminals. suppression of barium currents of cones by baclofen was dose-dependent. moreover, barium currents of cones were potentiated by background illumination, as compared with those recorded in the dark. 6,7-dinitroquinoxaline-2,3-dione, an antagonist of non-nmda receptors that hyperpolarizes horizontal cells and reduces gaba release from these cells, and saclofen, a gaba(b) receptor antagonist, both potentiated barium currents of cones in the dark, thereby mimicking the effects of background illumination. it is suggested that changes in calcium influx into the cone synaptic terminals due to activation of gaba, receptors may provide a negative feedback mechanism for regulating signal transmission between cones and second-order neurons in the retina by modifying the amount of glutamate released from the cones. (c) 2005 published by elsevier ltd on behalf of ibro. |
| WOS关键词 | GAMMA-AMINOBUTYRIC-ACID ; TIGER SALAMANDER RETINA ; SENSITIVE CALCIUM-CHANNEL ; OUTER PLEXIFORM LAYER ; FACILITATE L-TYPE ; HORIZONTAL CELLS ; GLUTAMATE RELEASE ; B RECEPTORS ; IMMUNOCYTOCHEMICAL LOCALIZATION ; TRANSMITTER RELEASE |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000228228300009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377168 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, XL |
| 作者单位 | 1.Fudan Univ, Inst Brain Sci, Inst Neurobiol, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Grad Sch, Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, J,Zhao, JW,Du, JL,et al. Functional gaba(b) receptors are expressed at the cone photoreceptor terminals in bullfrog retina[J]. Neuroscience,2005,132(1):103-113. |
| APA | Liu, J,Zhao, JW,Du, JL,&Yang, XL.(2005).Functional gaba(b) receptors are expressed at the cone photoreceptor terminals in bullfrog retina.Neuroscience,132(1),103-113. |
| MLA | Liu, J,et al."Functional gaba(b) receptors are expressed at the cone photoreceptor terminals in bullfrog retina".Neuroscience 132.1(2005):103-113. |
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来源：中国科学院大学
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