Expression of thymosin beta4 mrna by activated microglia in the denervated hippocampus
文献类型：期刊论文
| 作者 | Dong, JH; Ying, GX; Liu, X; Wang, WY; Wang, Y; Ni, ZM; Zhou, CF |
| 刊名 | Neuroreport
 |
| 出版日期 | 2005-10-17 |
| 卷号 | 16期号:15页码:1629-1633 |
| 关键词 | Actin-sequestering protein Entorhinal deafferentation Microglial activation Neurodegeneration |
| ISSN号 | 0959-4965 |
| 通讯作者 | Zhou, cf() |
| 英文摘要 | Thymosin 4 is a major actin-sequestering molecule. here, we report a prominent upregulation of thymosin beta 4 in the hippocampus following entorhinal deafferentation. northern blotting displayed a transient increase of thymosin beta 4 mrna in the deafferented hippocampus by 1.8, 2.3,1.3 and 1.1-fold of controls, respectively, at 1, 3, 7 and 15 days post-lesion. in-situ hybridization confirmed that the induction of thymosin beta 4 mrna specifically occurred in the entorhinally denervated zones of the hippocampus. the double labeling of in-situ hybridization for thymosin beta 4 nnrna with isolectin b4 cytochemistry showed that isolectin b4-positive microglial cells are responsible for deafferentation-induced thymosin beta 4 mrna expression. the results suggest that thymosin beta 4 may participate in the process of microglial activation, which is the earliest event in lesion-induced plasticity. |
| WOS关键词 | ACTIN-SEQUESTERING PEPTIDE ; PERFORANT PATH ; IN-VIVO ; CELLS ; LESION ; MACROPHAGES ; NEURONS ; FIBERS ; BRAIN ; LIGHT |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000233073900005 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377221 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, CF |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Neurobiol,Shanghai Inst Physiol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, JH,Ying, GX,Liu, X,et al. Expression of thymosin beta4 mrna by activated microglia in the denervated hippocampus[J]. Neuroreport,2005,16(15):1629-1633. |
| APA | Dong, JH.,Ying, GX.,Liu, X.,Wang, WY.,Wang, Y.,...&Zhou, CF.(2005).Expression of thymosin beta4 mrna by activated microglia in the denervated hippocampus.Neuroreport,16(15),1629-1633. |
| MLA | Dong, JH,et al."Expression of thymosin beta4 mrna by activated microglia in the denervated hippocampus".Neuroreport 16.15(2005):1629-1633. |
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来源：中国科学院大学
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