G protein beta 3 subunit gene variants and essential hypertension in the northern chinese han population
文献类型：期刊论文
| 作者 | Li, B; Ge, DL; Wang, YL; Zhao, WY; Zhou, XY; Gu, DF; Chen, RS |
| 刊名 | Annals of human genetics
 |
| 出版日期 | 2005-07-01 |
| 卷号 | 69页码:468-473 |
| 关键词 | G protein beta 3 subunit gene Haplotype Association study Hypertension |
| ISSN号 | 0003-4800 |
| DOI | 10.1111/j.1529-8817.2005.00172.x |
| 通讯作者 | Chen, rs() |
| 英文摘要 | Recently a novel c825t polymorphism in the g protein beta 3 subunit gene was identified that showed an association with hypertension in a german population; the results of studies in other populations have been inconsistent. to examine the contribution of gnb3 polymorphisms to the development of hypertension in the northern chinese han population, we conducted a case-control study consisting of 501 hypertensive cases and 503 controls using the g(-350)a, c825t and c1429t polymorphisms. genotypes of samples were determined by pcr, and restriction digestion. single locus analysis showed a significant association between g(-350)a and hypertension (p = 0.01) but no association for c825t or c1429t. the three polymorphisms were in tight linkage disequilibrium (d' = -1 for g(-350)a-c825t, d' = 0.92 for c825t-c1429t) and a total of 7 haplotypes were observed in the entire population. haplotype a-c-c was found to be significantly related to hypertension (p = 0.032) and a-c-c carriers had a more than two-fold higher risk of hypertension than non-carriers, after adjustment for bmi and glucose. in conclusion, our study suggests that g(-350)a is a potential functional polymorphism that may be related to hypertension, whereas the c825t and c1429t polymorphisms are not associated with hypertension in the northern chinese han population. |
| WOS关键词 | BLOOD-PRESSURE ; ASSOCIATION ; HAPLOTYPES ; IDENTIFICATION ; TESTS |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000230637800011 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377300 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, RS |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Natl Human Genome Ctr, Beijing, Peoples R China 4.Chinese Acad Med Sci, Cardiovasc Inst, Div Populat Genet & Prevent, Beijing 100037, Peoples R China 5.Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100037, Peoples R China 6.Peking Union Med Coll, Beijing, Peoples R China 7.Inst Biotechnol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, B,Ge, DL,Wang, YL,et al. G protein beta 3 subunit gene variants and essential hypertension in the northern chinese han population[J]. Annals of human genetics,2005,69:468-473. |
| APA | Li, B.,Ge, DL.,Wang, YL.,Zhao, WY.,Zhou, XY.,...&Chen, RS.(2005).G protein beta 3 subunit gene variants and essential hypertension in the northern chinese han population.Annals of human genetics,69,468-473. |
| MLA | Li, B,et al."G protein beta 3 subunit gene variants and essential hypertension in the northern chinese han population".Annals of human genetics 69(2005):468-473. |
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来源：中国科学院大学
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