Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (l-lactide-co-2-methyl-2-carboxyl-propylene carbonate)
文献类型：期刊论文
| 作者 | Guan, HL; Xie, ZG; Zhang, PB; Wang, X; Chen, XS; Wang, XH; Jing, XB |
| 刊名 | Journal of polymer science part a-polymer chemistry
 |
| 出版日期 | 2005-10-15 |
| 卷号 | 43期号:20页码:4771-4780 |
| 关键词 | Biodegradable Carbonate Functionalization of polymers Polylactide Ring-opening polymerization |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.20942 |
| 通讯作者 | Jing, xb() |
| 英文摘要 | An amphiphilic block copolymer, poly(ethylene glycol)-block-poly(l-lactideco-2-methyl-2-benzoxycarbonyl-propylene carbonate) [peg-b-p(la-co-mbc)], was synthesized in bulk by the ring-opening polymerization of l-lactide with 2-methyl-2-benzoxycarbonyl-propylene carbonate (mbc) in the presence of poly(ethylene glycol) as a macroinitiator with diethyl zinc as a catalyst. the subsequent catalytic hydrogenation of peg-b-p(la-co-mbc) with palladium hydroxide on activated charcoal (20%) as a catalyst was carried out to obtain the corresponding linear copolymer poly(ethyleneglycol)-block-poly(l-lactide-co-2-methyl-2-carboxyl-propylenecarbonate) [peg-b-p(la-co-mcc)] with pendant carboxyl groups. dsc analysis indicated that the glass-transition temperature (t-g) of peg-b-ma-co-mbq decreased with increasing mbc content in the copolymer, and t-g of peg-b-p(la-co-mcc) was higher than that of the corresponding peg-b-p(la-co-mbc). the in vitro degradation rate of peg-b-p(la-co-mcc) in the presence of proteinase k was faster than that of peg-b-p(la-co-mbc), and the cytotoxicity of peg-b-p(la-co-mcc) to chondrocytes from human fetal arthrosis was lower than that of poly (l-lactide). (c) 2005 wiley periodicals, inc. |
| WOS关键词 | RING-OPENING POLYMERIZATION ; ALIPHATIC POLYESTERS ; POLY(LACTIC ACID-CO-LYSINE) ; EPSILON-CAPROLACTONE ; POLY(ESTER AMIDE)S ; ACID) DERIVATIVES ; PENDANT GROUPS ; L-LACTIDE ; ROUTE ; 5-METHYL-5-BENZYLOXYCARBONYL-1,3-DIOXAN-2-ONE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000232407200009 |
| 出版者 | JOHN WILEY & SONS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377375 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jing, XB |
| 作者单位 | 1.Acad Sinica, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, HL,Xie, ZG,Zhang, PB,et al. Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (l-lactide-co-2-methyl-2-carboxyl-propylene carbonate)[J]. Journal of polymer science part a-polymer chemistry,2005,43(20):4771-4780. |
| APA | Guan, HL.,Xie, ZG.,Zhang, PB.,Wang, X.,Chen, XS.,...&Jing, XB.(2005).Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (l-lactide-co-2-methyl-2-carboxyl-propylene carbonate).Journal of polymer science part a-polymer chemistry,43(20),4771-4780. |
| MLA | Guan, HL,et al."Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (l-lactide-co-2-methyl-2-carboxyl-propylene carbonate)".Journal of polymer science part a-polymer chemistry 43.20(2005):4771-4780. |
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来源：中国科学院大学
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