An environmentally friendly process for the preparation of 16-dehydropregnenolone acetate
文献类型：期刊论文
| 作者 | Zhang, Y; Liu, YY; Cheng, XX; Wang, XS; Zhang, BW |
| 刊名 | Chinese journal of chemistry
 |
| 出版日期 | 2005-06-01 |
| 卷号 | 23期号:6页码:753-756 |
| 关键词 | 16-dpa Photooxygenation Pseudodiosgenin diacetate |
| ISSN号 | 1001-604X |
| 通讯作者 | Zhang, y() |
| 英文摘要 | Instead of environmentally toxic chromium oxidant, singlet oxygen generated photochemically was used as environmentally friendly and benign oxidizing agent to accomplish the transformation of pseudodiosgenin diacetate to diosone efficiently in a low toxic and less expensive solvent acetone. accordingly 16-dehydropregnenolone aceate (16-dpa), an important intermediate for preparation of steroidal drugs, was prepared in good yield (75%) when photoreaction was run in acetone/acetic anhydride/pyridine system. the mild reaction condition as well as simple and environmentally friendly process made the method commercially viable and important for production of 16-dpa in industrial scale. |
| WOS关键词 | SINGLET OXYGEN ; SENSITIZED PHOTOOXYGENATION ; SAPOGENINS ; CONVERSION ; PSEUDOSAPOGENINS ; STEROLS ; OLEFINS ; ENONES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000229408100020 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377388 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Y |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Liu, YY,Cheng, XX,et al. An environmentally friendly process for the preparation of 16-dehydropregnenolone acetate[J]. Chinese journal of chemistry,2005,23(6):753-756. |
| APA | Zhang, Y,Liu, YY,Cheng, XX,Wang, XS,&Zhang, BW.(2005).An environmentally friendly process for the preparation of 16-dehydropregnenolone acetate.Chinese journal of chemistry,23(6),753-756. |
| MLA | Zhang, Y,et al."An environmentally friendly process for the preparation of 16-dehydropregnenolone acetate".Chinese journal of chemistry 23.6(2005):753-756. |
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来源：中国科学院大学
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