Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives
文献类型：期刊论文
| 作者 | Xia, GX; Li, JF; Peng, AM; Lai, SN; Zhang, SJ; Shen, JS; Liu, ZH; Chen, XJ; Ji, RY |
| 刊名 | Bioorganic & medicinal chemistry letters
 |
| 出版日期 | 2005-06-02 |
| 卷号 | 15期号:11页码:2790-2794 |
| 关键词 | Pyrido[1,2-e]purin-4(3h)-one Pde5 inhibitor Sildenafil Erectile dysfunction |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2005.03.102 |
| 通讯作者 | Shen, js() |
| 英文摘要 | Synthesis and primary sar of a novel series of 2-phenylpyrido[1,2-e]purin-4(3h)-one derivatives with piperazinyl sulfonamide substituents were described herein. as potential pde5 inhibitors for erectile dysfunction (ed) treatment, representative compounds exhibit improved selectivity versus pde1 and pde6. meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro. (c) 2005 elsevier ltd. all rights reserved. |
| WOS关键词 | MALE ERECTILE DYSFUNCTION ; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES ; SELECTIVE PDE5 INHIBITORS ; POTENT ; SILDENAFIL ; CAVERNOSUM ; ANALOGS ; RELAXATION ; EXPRESSION ; ISOFORMS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000229665600019 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377415 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, JS |
| 作者单位 | 1.Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, GX,Li, JF,Peng, AM,et al. Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives[J]. Bioorganic & medicinal chemistry letters,2005,15(11):2790-2794. |
| APA | Xia, GX.,Li, JF.,Peng, AM.,Lai, SN.,Zhang, SJ.,...&Ji, RY.(2005).Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives.Bioorganic & medicinal chemistry letters,15(11),2790-2794. |
| MLA | Xia, GX,et al."Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3h)-one derivatives".Bioorganic & medicinal chemistry letters 15.11(2005):2790-2794. |
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来源：中国科学院大学
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