Predicting protein secondary structure and solvent accessibility with an improved multiple linear regression method
文献类型：期刊论文
| 作者 | Qin, SB; He, Y; Pan, XM |
| 刊名 | Proteins-structure function and bioinformatics
 |
| 出版日期 | 2005-11-15 |
| 卷号 | 61期号:3页码:473-480 |
| 关键词 | Protein secondary structure prediction Solvent accessibility prediction Multiple linear regression Protein folding Pssm |
| ISSN号 | 0887-3585 |
| DOI | 10.1002/prot.20645 |
| 通讯作者 | Pan, xm() |
| 英文摘要 | We have improved the multiple linear regression (mlr) algorithm for protein secondary structure prediction by combining it with the evolutionary information provided by multiple sequence alignment of psi-blast. on the cb513 dataset, the three states average overall per-residue accuracy, q(3), reached 76.4%, while segment overlap accuracy, sov99, reached 73.2%, using a rigorous jackknife procedure and the strictest reduction of eight states dssp definition to three states. this represents an improvement of approximately 5% on overall per-residue accuracy compared with previous work. the relative solvent accessibility prediction also benefited from this combination of methods. the system achieved 77.7% average jackknifed accuracy for two states prediction based on a 25% relative solvent accessibility mode, with a mathews' correlation coefficient of 0.548. the improved mlr secondary structure and relative solvent accessibility prediction server is available at http://spg.biosci. tsinghua.edu.cn/. proteins 2005;61:473-480. (c) 2005 wiley-liss, inc. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000233029800003 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377513 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Pan, XM |
| 作者单位 | 1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100864, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, SB,He, Y,Pan, XM. Predicting protein secondary structure and solvent accessibility with an improved multiple linear regression method[J]. Proteins-structure function and bioinformatics,2005,61(3):473-480. |
| APA | Qin, SB,He, Y,&Pan, XM.(2005).Predicting protein secondary structure and solvent accessibility with an improved multiple linear regression method.Proteins-structure function and bioinformatics,61(3),473-480. |
| MLA | Qin, SB,et al."Predicting protein secondary structure and solvent accessibility with an improved multiple linear regression method".Proteins-structure function and bioinformatics 61.3(2005):473-480. |
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来源：中国科学院大学
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