Oct4 pseudogenes are transcribed in cancers
文献类型：期刊论文
| 作者 | Suo, GL; Han, J; Wang, X; Zhang, JY; Zhao, YN; Zhao, YH; Dai, JW |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2005-12-02 |
| 卷号 | 337期号:4页码:1047-1051 |
| 关键词 | Oct4 Pseudogene Transcription Cancer cell line Cancer tissue |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2005.09.157 |
| 通讯作者 | Dai, jw() |
| 英文摘要 | Octamer-binding transcription factor 4 (oct4) plays a critical role for maintaining pluripotent and the self-renewing state of stem cells. recent studies demonstrated that oct4 gene was expressed in human cancers. six pseudogenes of oct4 have been proposed by using bioinformatics approach to analyze the genomic nucleotide sequences. here, we reported that an oct4 pseudogene localized in human chromosome 10 (oct4-pg5) and a pseudogene in chromosome 8 (oct4-pg1)were transcribed in cancer cell lines as well as cancer tissues tested, and the), were not found transcribed in embryonic carcinoma cells, human fibroblasts, and normal tissues tested. our results suggest that pseudogenes oct4-pg5 and oct4-pg1 may be involved in the regulation of oct4 gene activity thus might be pertinent to carcinogenesis. transcription of these oct4 pseudogenes may have contributed artifacts to the current knowledge of oct4 gene expression and function in cancers. (c) 2005 elsevier inc. all rights reserved. |
| WOS关键词 | STEM-CELLS ; MAMMALIAN EMBRYO ; POU-DOMAIN ; EXPRESSION ; PROTEIN ; GENE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000233120600004 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377563 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, JW |
| 作者单位 | 1.Chinese Acad Sci, Ctr Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Suo, GL,Han, J,Wang, X,et al. Oct4 pseudogenes are transcribed in cancers[J]. Biochemical and biophysical research communications,2005,337(4):1047-1051. |
| APA | Suo, GL.,Han, J.,Wang, X.,Zhang, JY.,Zhao, YN.,...&Dai, JW.(2005).Oct4 pseudogenes are transcribed in cancers.Biochemical and biophysical research communications,337(4),1047-1051. |
| MLA | Suo, GL,et al."Oct4 pseudogenes are transcribed in cancers".Biochemical and biophysical research communications 337.4(2005):1047-1051. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。