Protein-protein interaction prediction with correlated gene ontology
文献类型：期刊论文
| 作者 | Qian, M; Wang, JZ |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2005-05-01 |
| 卷号 | 32期号:5页码:449-455 |
| 关键词 | Protein-protein interaction (ppi)) Correlated Gene ontology (go) Naive bayesian |
| ISSN号 | 1000-3282 |
| 通讯作者 | Wang, jz() |
| 英文摘要 | The cellular processes in cells are controlled by protein-protein interactions (ppi), and comprehensive ppi maps are important to understand the complicated regulatory, metabolic and signaling pathways. recently, new parameters for ppi prediction are under discovering. here, a naive bayesian algorithm with the correlated gene ontology (go) was used for ppi prediction. the characteristic pairs of go terms was demonstrated by training a non-redundant ppi data set from two online budding yeast databases, and the probability about this two correlated go terms was also obtained. the accuracy of the prediction was tested by both positive and negative control data. the approach can distinguish them properly, with a satisfied sensitivity and low false positive rate. after comparing the prediction result to the data derived from high-throughput experiments, it is proved that the method is more sensitive and efficient than other means. furthermore, some new insightful knowledge about interactions of the proteins will be found using this prediction approach, and the prediction is very helpful to the laboratory experiments. |
| WOS关键词 | SACCHAROMYCES-CEREVISIAE ; NETWORKS ; INHIBITION ; ANNOTATION ; COMPLEXES ; GENOMICS ; MITOSIS ; AURORA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000229250000011 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377572 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, JZ |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, M,Wang, JZ. Protein-protein interaction prediction with correlated gene ontology[J]. Progress in biochemistry and biophysics,2005,32(5):449-455. |
| APA | Qian, M,&Wang, JZ.(2005).Protein-protein interaction prediction with correlated gene ontology.Progress in biochemistry and biophysics,32(5),449-455. |
| MLA | Qian, M,et al."Protein-protein interaction prediction with correlated gene ontology".Progress in biochemistry and biophysics 32.5(2005):449-455. |
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来源：中国科学院大学
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