Molecular character of the recombinant antitumor lectin from the edible mushroom agrocybe aegerita
文献类型：期刊论文
| 作者 | Yang, N; Tong, X; Xiang, Y; Zhang, Y; Liang, Y; Sun, H; Wang, DC |
| 刊名 | Journal of biochemistry
 |
| 出版日期 | 2005-08-01 |
| 卷号 | 138期号:2页码:145-150 |
| 关键词 | Antitumor Apoptosis Galectin Homodimer Mushroom |
| ISSN号 | 0021-924X |
| DOI | 10.1093/jb/mvi109 |
| 通讯作者 | Sun, h() |
| 英文摘要 | The lectin from agrocybe aegerita (aal) has been found to possess potent tumor-suppressing function and tumor cell apoptosis-inducing activity. in this paper, we report the full sequence, the active expression of the gene encoding aal at a high level and bioassay of the binding property with lactose, apoptosis-inducing activity and dnase activity of recombinant aal (raal). the results reveal that aal is a member of the galectin family and the dimeric form is the active unit for the functional performance. the raal showed comparable tumor cell apoptosis-inducing activity with the wild aal but no dnase activity at all. the molecular characters revealed by this study are significant for the in-depth investigation of the functional mechanism of this interesting protein. |
| WOS关键词 | GALECTINS ; FAMILY ; PROLIFERATION ; MYCELIA ; PROTEIN |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000231449400005 |
| 出版者 | JAPANESE BIOCHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377583 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Sun, H |
| 作者单位 | 1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Ctr Struct & Mol Biol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, N,Tong, X,Xiang, Y,et al. Molecular character of the recombinant antitumor lectin from the edible mushroom agrocybe aegerita[J]. Journal of biochemistry,2005,138(2):145-150. |
| APA | Yang, N.,Tong, X.,Xiang, Y.,Zhang, Y.,Liang, Y.,...&Wang, DC.(2005).Molecular character of the recombinant antitumor lectin from the edible mushroom agrocybe aegerita.Journal of biochemistry,138(2),145-150. |
| MLA | Yang, N,et al."Molecular character of the recombinant antitumor lectin from the edible mushroom agrocybe aegerita".Journal of biochemistry 138.2(2005):145-150. |
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来源：中国科学院大学
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