Study on the self-setting property and the in vitro bioactivity of beta-ca2sio4
文献类型：期刊论文
| 作者 | Gou, ZG; Chang, J; Zhai, WY; Wang, JY |
| 刊名 | Journal of biomedical materials research part b-applied biomaterials
 |
| 出版日期 | 2005-05-01 |
| 卷号 | 73b期号:2页码:244-251 |
| 关键词 | Beta-dicalcium silicate Self-setting Bioactivity Injectability Cell proliferation Bone cement |
| ISSN号 | 1552-4973 |
| DOI | 10.1002/jbm.b.30203 |
| 通讯作者 | Chang, j() |
| 英文摘要 | This study sought to investigate the physical and chemical properties of β-dicalcium silicate (β-ca2sio4) in order to evaluate its use as an injectable bioactive cement filler. workable β-ca2sio4 pastes with a liquid-to-powder (lip) ratio of 1.0-1.2 could be injected for 10-30 min (nozzle diameter 2.0 mm) and enabled initial setting times of 60-180 min. the setting process yielded cellular structures with compressive strengths of 4.8-28.8 mpa after 2-28 days. the paste was soaked in simulated body fluid (sbf), and the results demonstrated that it exhibited a moderate degradation and could induce carbonated hydroxyapatite formation. the ionic products of the paste dissolution enhanced a proliferative response of fibroblasts compared with the cells cultured alone, and this cement could also support adhesion and spreading of the mesenchymal stem cells. finally, with the use of gentamicin as a model drug, it was found that a high dose of drug release from the paste was maintained for 14 days, and there was a sustained release over 4 weeks. this combination of properties indicates that the novel β-ca2sio4 cement might be suitable for potential applications in the biomedical field, preferentially as materials for bone/dental repair and controlled drug-delivery systems. © 2005 wiley periodicals, inc. |
| WOS关键词 | BETA-DICALCIUM SILICATE ; LOADED BONE-CEMENT ; HUMAN OSTEOBLASTS ; CALCIUM PHOSPHATES ; IONIC PRODUCTS ; EXPRESSION ; HYDRATION ; BEHAVIOR ; RELEASE ; REPAIR |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000228935300006 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377637 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chang, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200050, Peoples R China 3.E China Normal Univ, Sch Biol Sci, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gou, ZG,Chang, J,Zhai, WY,et al. Study on the self-setting property and the in vitro bioactivity of beta-ca2sio4[J]. Journal of biomedical materials research part b-applied biomaterials,2005,73b(2):244-251. |
| APA | Gou, ZG,Chang, J,Zhai, WY,&Wang, JY.(2005).Study on the self-setting property and the in vitro bioactivity of beta-ca2sio4.Journal of biomedical materials research part b-applied biomaterials,73b(2),244-251. |
| MLA | Gou, ZG,et al."Study on the self-setting property and the in vitro bioactivity of beta-ca2sio4".Journal of biomedical materials research part b-applied biomaterials 73b.2(2005):244-251. |
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来源：中国科学院大学
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