Anti-angiogenic activities of chitooligosaccharides
文献类型：期刊论文
| 作者 | Wu, Haige1,2,3; Yao, Ziang2; Bal, Xuefang1; Du, Yuguang1; Lin, Bingcheng1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2008-07-04 |
| 卷号 | 73期号:1页码:105-110 |
| ISSN号 | issn: 0144-8617 |
| 关键词 | chitoologosaccharides endothelial cell CAM angiogenesis |
| 通讯作者 | 杜昱光 |
| 产权排序 | 1;1 |
| 英文摘要 | chitooligosaccharides (cos) was obtained from chitosan by depolymerization with enzyme and analyzed by hplc and tof-ms, and the results indicated that the polymerization degree of cos was 2-18. in order to explore the anti-angiogenic activities of cos, the effect of cos on chicken chorioallantoic membrane (cam) angiogenesis and on proliferation, migration and tube formation of human umbilical vein endothelial cells (huvecs) induced by human hepatoma carcinoma cells (hcc) culture fluid was measured. the results showed cos had no toxicity to normal huvecs, but could inhibit the cam angiogenesis and the proliferation, migration and tube formation of induced huvecs. all of these results indicate that cos have potential anti-angiogenic activities and can counteract the stimulation of hcc-culture-fluid on endothelial cells at a certain level. (c) 2007 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | cancer ; metalloproteinases ; strategies ; chitosan ; growth ; cells |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000255450200013 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101043]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Dalian Univ, Bioengn Coll, Dalian 116622, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Haige,Yao, Ziang,Bal, Xuefang,et al. Anti-angiogenic activities of chitooligosaccharides[J]. carbohydrate polymers,2008,73(1):105-110. |
| APA | Wu, Haige,Yao, Ziang,Bal, Xuefang,Du, Yuguang,&Lin, Bingcheng.(2008).Anti-angiogenic activities of chitooligosaccharides.carbohydrate polymers,73(1),105-110. |
| MLA | Wu, Haige,et al."Anti-angiogenic activities of chitooligosaccharides".carbohydrate polymers 73.1(2008):105-110. |
入库方式： OAI收割
来源：大连化学物理研究所
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