Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus
文献类型：期刊论文
| 作者 | Wang, Y; Ying, GX; Liu, X; Wang, WY; Dong, JH; Ni, ZM; Zhou, CF |
| 刊名 | European journal of neuroscience
 |
| 出版日期 | 2005-05-01 |
| 卷号 | 21期号:9页码:2336-2346 |
| 关键词 | Astrocyte Axonal sprouting Dendritic remodeling Entorhinal deafferentation Phagocytosis |
| ISSN号 | 0953-816X |
| DOI | 10.1111/j.1460-9568.2005.04093.x |
| 通讯作者 | Zhou, cf() |
| 英文摘要 | It has been widely demonstrated that eph receptors and their ephrin ligands play multiple pivotal roles in the development of the nervous system. however, less is known about their roles in the adult brain. here we reported the expression of ephrin-b1 and its cognate ephb receptors in the adult mouse hippocampus at 3, 7, 15, 30 and 60 days after transections of the entorhinal afferents. in situ hybridization and immunohistochemistry showed the time-dependent up-regulation of ephrin-b1 in the denervated areas of the hippocampus, which initiated at 3 days postlesion (dpl), reached maximal levels at 7-15 dpl, remained slightly elevated at 30 dpl and recovered to normal levels by 60 dpl. double labeling of ephrin-b1 and glial fibrillary acidic protein revealed that ephrin-b1-expressing cells in the denervated areas were reactive astrocytes. furthermore, a ligand-binding assay using ephrin-b1/fc chimera protein also displayed the up-regulation of ephb receptors in the denervated areas of the hippocampus in a similar manner to that of ephrin-b1. within the first week postlesion, the ephb receptors were expressed by reactive astrocytes. after 7 dpl, however, ephb receptors were expressed not only by reactive astrocytes but also first by sprouting axons and later by regrowing dendrites. these results suggest that the ephrin-b1/ephb system may participate in the lesion-induced plasticity processes in the adult mouse hippocampus. |
| WOS关键词 | ENTORHINAL CORTEX LESION ; CENTRAL-NERVOUS-SYSTEM ; RAT DENTATE GYRUS ; VULGARIS-LEUKOAGGLUTININ PHAL ; ELECTRON-MICROSCOPIC ANALYSIS ; TYROSINE KINASES ; SPINAL-CORD ; NEURITE OUTGROWTH ; FASCIA-DENTATA ; TIME COURSE |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000229284100004 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377721 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, CF |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Physiol,Key Lab Neurobiol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Y,Ying, GX,Liu, X,et al. Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus[J]. European journal of neuroscience,2005,21(9):2336-2346. |
| APA | Wang, Y.,Ying, GX.,Liu, X.,Wang, WY.,Dong, JH.,...&Zhou, CF.(2005).Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus.European journal of neuroscience,21(9),2336-2346. |
| MLA | Wang, Y,et al."Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus".European journal of neuroscience 21.9(2005):2336-2346. |
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来源：中国科学院大学
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