中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus

文献类型:期刊论文

作者Wang, Y; Ying, GX; Liu, X; Wang, WY; Dong, JH; Ni, ZM; Zhou, CF
刊名European journal of neuroscience
出版日期2005-05-01
卷号21期号:9页码:2336-2346
关键词Astrocyte Axonal sprouting Dendritic remodeling Entorhinal deafferentation Phagocytosis
ISSN号0953-816X
DOI10.1111/j.1460-9568.2005.04093.x
通讯作者Zhou, cf()
英文摘要It has been widely demonstrated that eph receptors and their ephrin ligands play multiple pivotal roles in the development of the nervous system. however, less is known about their roles in the adult brain. here we reported the expression of ephrin-b1 and its cognate ephb receptors in the adult mouse hippocampus at 3, 7, 15, 30 and 60 days after transections of the entorhinal afferents. in situ hybridization and immunohistochemistry showed the time-dependent up-regulation of ephrin-b1 in the denervated areas of the hippocampus, which initiated at 3 days postlesion (dpl), reached maximal levels at 7-15 dpl, remained slightly elevated at 30 dpl and recovered to normal levels by 60 dpl. double labeling of ephrin-b1 and glial fibrillary acidic protein revealed that ephrin-b1-expressing cells in the denervated areas were reactive astrocytes. furthermore, a ligand-binding assay using ephrin-b1/fc chimera protein also displayed the up-regulation of ephb receptors in the denervated areas of the hippocampus in a similar manner to that of ephrin-b1. within the first week postlesion, the ephb receptors were expressed by reactive astrocytes. after 7 dpl, however, ephb receptors were expressed not only by reactive astrocytes but also first by sprouting axons and later by regrowing dendrites. these results suggest that the ephrin-b1/ephb system may participate in the lesion-induced plasticity processes in the adult mouse hippocampus.
WOS关键词ENTORHINAL CORTEX LESION ; CENTRAL-NERVOUS-SYSTEM ; RAT DENTATE GYRUS ; VULGARIS-LEUKOAGGLUTININ PHAL ; ELECTRON-MICROSCOPIC ANALYSIS ; TYROSINE KINASES ; SPINAL-CORD ; NEURITE OUTGROWTH ; FASCIA-DENTATA ; TIME COURSE
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
语种英语
WOS记录号WOS:000229284100004
出版者BLACKWELL PUBLISHING
URI标识http://www.irgrid.ac.cn/handle/1471x/2377721
专题中国科学院大学
通讯作者Zhou, CF
作者单位Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Physiol,Key Lab Neurobiol, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Wang, Y,Ying, GX,Liu, X,et al. Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus[J]. European journal of neuroscience,2005,21(9):2336-2346.
APA Wang, Y.,Ying, GX.,Liu, X.,Wang, WY.,Dong, JH.,...&Zhou, CF.(2005).Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus.European journal of neuroscience,21(9),2336-2346.
MLA Wang, Y,et al."Induction of ephrin-b1 and ephb receptors during denervation-induced plasticity in the adult mouse hippocampus".European journal of neuroscience 21.9(2005):2336-2346.

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来源:中国科学院大学

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