中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model

文献类型:期刊论文

作者Dou, Jiangli1,2; Xu, Qingsong1,2; Tan, Chengyu1; Wang, Wenxia1,2; Du, Yuguang1; Bai, Xuefang1; Ma, Xiaojun1
刊名carbohydrate polymers
出版日期2009-01-05
卷号75期号:1页码:119-124
关键词Chitosan oligosaccharides Neutrophil Superoxide Apoptosis Inflammation
ISSN号issn: 0144-8617
产权排序1;1
通讯作者杜昱光
英文摘要to investigate the effects of chitosan oligosaccharides (cos) on the neutrophils from glycogen-induced peritonitis mice model, the production of superoxide and hydrogen peroxide, myeloperoxidase (mpo) release as well as apoptosis were measured. we found that 100 mu g/ml cos supplementation could induce the production of superoxide and hydrogen peroxide by neutrophils, meanwhile, cos promoted the apoptosis of peritoneal neutrophils, whereas the mpo release was decreased. furthermore, superoxide dismutase (sod) administration could abolish the pro-apoptotic effects mediated by cos. these results demonstrated that cos exerted pro-apoptotic effects on neutrophils, and superoxide played an important role in neutrophil apoptosis caused by cos. by the use of inhibitors of plo and pi3k respectively, administration of 1-butanol and wortamannin decreased the generation of superoxide stimulated by cos. the production of superoxide caused by cos resulted from the activation of plo and pi3k to some extent. (c) 2008 elsevier ltd. all rights reserved.
WOS标题词science & technology ; physical sciences
类目[WOS]chemistry, applied ; chemistry, organic ; polymer science
研究领域[WOS]chemistry ; polymer science
关键词[WOS]phospholipase-d ; polymorphonuclear leukocytes ; phosphatidic-acid ; nitric-oxide ; apoptosis ; release ; chitin ; chitooligosaccharides ; myeloperoxidase ; involvement
收录类别SCI
原文出处true
语种英语
WOS记录号WOS:000260148600019
公开日期2010-11-30
源URL[http://159.226.238.44/handle/321008/101049]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Dou, Jiangli,Xu, Qingsong,Tan, Chengyu,et al. Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model[J]. carbohydrate polymers,2009,75(1):119-124.
APA Dou, Jiangli.,Xu, Qingsong.,Tan, Chengyu.,Wang, Wenxia.,Du, Yuguang.,...&Ma, Xiaojun.(2009).Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model.carbohydrate polymers,75(1),119-124.
MLA Dou, Jiangli,et al."Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model".carbohydrate polymers 75.1(2009):119-124.

入库方式: OAI收割

来源:大连化学物理研究所

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