Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model
文献类型：期刊论文
| 作者 | Dou, Jiangli1,2; Xu, Qingsong1,2; Tan, Chengyu1; Wang, Wenxia1,2; Du, Yuguang1; Bai, Xuefang1; Ma, Xiaojun1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2009-01-05 |
| 卷号 | 75期号:1页码:119-124 |
| 关键词 | Chitosan oligosaccharides Neutrophil Superoxide Apoptosis Inflammation |
| ISSN号 | issn: 0144-8617 |
| 产权排序 | 1;1 |
| 通讯作者 | 杜昱光 |
| 英文摘要 | to investigate the effects of chitosan oligosaccharides (cos) on the neutrophils from glycogen-induced peritonitis mice model, the production of superoxide and hydrogen peroxide, myeloperoxidase (mpo) release as well as apoptosis were measured. we found that 100 mu g/ml cos supplementation could induce the production of superoxide and hydrogen peroxide by neutrophils, meanwhile, cos promoted the apoptosis of peritoneal neutrophils, whereas the mpo release was decreased. furthermore, superoxide dismutase (sod) administration could abolish the pro-apoptotic effects mediated by cos. these results demonstrated that cos exerted pro-apoptotic effects on neutrophils, and superoxide played an important role in neutrophil apoptosis caused by cos. by the use of inhibitors of plo and pi3k respectively, administration of 1-butanol and wortamannin decreased the generation of superoxide stimulated by cos. the production of superoxide caused by cos resulted from the activation of plo and pi3k to some extent. (c) 2008 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | phospholipase-d ; polymorphonuclear leukocytes ; phosphatidic-acid ; nitric-oxide ; apoptosis ; release ; chitin ; chitooligosaccharides ; myeloperoxidase ; involvement |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000260148600019 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101049]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dou, Jiangli,Xu, Qingsong,Tan, Chengyu,et al. Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model[J]. carbohydrate polymers,2009,75(1):119-124. |
| APA | Dou, Jiangli.,Xu, Qingsong.,Tan, Chengyu.,Wang, Wenxia.,Du, Yuguang.,...&Ma, Xiaojun.(2009).Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model.carbohydrate polymers,75(1),119-124. |
| MLA | Dou, Jiangli,et al."Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model".carbohydrate polymers 75.1(2009):119-124. |
入库方式： OAI收割
来源：大连化学物理研究所
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