Expression of hsg is essential for mouse blastocyst formation
文献类型：期刊论文
| 作者 | Jiang, GJ; Pan, L; Huang, XY; Han, M; Wen, JK; Sun, FZ |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2005-09-23 |
| 卷号 | 335期号:2页码:351-355 |
| 关键词 | Hsg Mitochondria Oocytes Preimplantation embryos Tubulin |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2005.07.088 |
| 通讯作者 | Wen, jk() |
| 英文摘要 | It has been shown recently that hyperplasia suppressor gene (hsg) is a powerful regulator for cell proliferation and has a critical role in mitochondrial fusion in many cells. however, little is known about its expression, localization, and function during oocyte maturation and early embryogenesis. in this study, with indirect immunofluorescent staining and western blotting, we found that hsg was expressed in mouse oocytes and preimplantation embryos which primarily exhibited a submembrane distribution pattern in the cytoplasm. moreover, hsg mainly associated with p-tubulin during oocyte maturation and early embryonic development. when mouse zygotes were injected with hsg antisense plasmid and cultured in vitro, their capacity to form blastocysts was severely impaired. our results indicate that hsg plays an essential role in mouse preimplantation development. (c) 2005 elsevier inc. all rights reserved. |
| WOS关键词 | MITOCHONDRIAL FUSION ; ACTIVE MITOCHONDRIA ; MAMMALIAN-CELLS ; PROTEIN ; TRANSLOCATION ; ASSOCIATION ; MICROSCOPY ; METABOLISM ; MITOFUSINS ; APOPTOSIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000231586600013 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377740 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wen, JK |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100080, Peoples R China 2.Hebei Med Univ, Inst Basic Med, Shijiazhuang 050017, Peoples R China 3.N China Coal Med Coll, Dept Biochem & Mol Biol, Tangshan 063000, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, GJ,Pan, L,Huang, XY,et al. Expression of hsg is essential for mouse blastocyst formation[J]. Biochemical and biophysical research communications,2005,335(2):351-355. |
| APA | Jiang, GJ,Pan, L,Huang, XY,Han, M,Wen, JK,&Sun, FZ.(2005).Expression of hsg is essential for mouse blastocyst formation.Biochemical and biophysical research communications,335(2),351-355. |
| MLA | Jiang, GJ,et al."Expression of hsg is essential for mouse blastocyst formation".Biochemical and biophysical research communications 335.2(2005):351-355. |
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来源：中国科学院大学
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