A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (sm735), mediates immunosuppressive effects in vitro and in vivo
文献类型：期刊论文
| 作者 | Zhou, WL; Wu, JM; Wu, QL; Wang, JX; Zhou, Y; Zhou, R; He, PI; Li, XY; Yang, YF; Zhang, Y |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 2005-11-01 |
| 卷号 | 26期号:11页码:1352-1358 |
| 关键词 | Artemisinin Non-steroidal anti-inflammatory agents Sm735 Immuno-suppressive activity |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2005.00232.x |
| 通讯作者 | Zuo, jp() |
| 英文摘要 | Aim: to study the immunosuppressive activity of sm735 {[3-(12-beta-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal antiinflammatory drug structure, with the aim of finding potential immunosuppressive agents. methods: concanavalin a (cona), lipopolysaccharide (lps), and mixed lymphocyte reaction (mlr), were used to induce the proliferation of splenocytes, and [h-3]-thymidine-incorporation was used to evaluate the proliferation of splenocytes. cytokine production was promoted with cona, lps, or pma plus ionomycin, and was detected with the enzyme-linked immunosorbent assay. dinitrofluorobenzene (dnfb) and sheep red blood cells (srbc) were used to induce delayed-type hypersensitivity and quantitative hemolysis of srbc (qhs) mouse models, as criteria for the evaluation of in vivo immune activity. results: sm735 strongly inhibited the proliferation of splenocytes induced by cona, lps, or mlr, with ic50 values of 0.33 mu mol/l, 0.27 mu mol/l, and 0.51 mu mol/l, respectively. when compared with a cc50 value of 53.1 mu mol/l, sm735 had a favorable safety range. sm735 dose-dependently inhibited proinflammatory cytokine production [including interleukins (il)-12, interferon (ifn)-gamma and il-6] induced by lps or pma plus ionomycin. upon cona stimulation, sm735 suppressed ifn-gamma in a dose-dependent manner, but did not affect il-2 secretion. sm735 also strongly suppressed both t-cell-mediated delayed-type hypersensitivity (dth) and b-cell-mediated qhs reactions. conclusion: sm735 had strong immunosuppressive activity in vitro and in vivo, suggesting a potential role for sm735 as an immunosuppressive agent, and established the groundwork for further research on sm735. |
| WOS关键词 | QINGHAOSU ARTEMISININ ; ANTIMALARIAL-DRUG ; MICE ; TOLERANCE ; RESPONSES ; IMMUNITY ; TRANSPLANTATION ; CYCLOSPORINE ; PROTEINS ; CELLS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000233209800012 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377770 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zuo, JP |
| 作者单位 | 1.Chinese Acad Sci, Lab Immunopharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Lab Synth Chem, Grad Sch, State Key Lab Drug Res,Shanghai Inst Mat Med,Inst, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, WL,Wu, JM,Wu, QL,et al. A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (sm735), mediates immunosuppressive effects in vitro and in vivo[J]. Acta pharmacologica sinica,2005,26(11):1352-1358. |
| APA | Zhou, WL.,Wu, JM.,Wu, QL.,Wang, JX.,Zhou, Y.,...&Zuo, JP.(2005).A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (sm735), mediates immunosuppressive effects in vitro and in vivo.Acta pharmacologica sinica,26(11),1352-1358. |
| MLA | Zhou, WL,et al."A novel artemisinin derivative, 3-(12-beta-artemisininoxy) phenoxyl succinic acid (sm735), mediates immunosuppressive effects in vitro and in vivo".Acta pharmacologica sinica 26.11(2005):1352-1358. |
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来源：中国科学院大学
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