Identification of potent type i metaps inhibitors by simple bioisosteric replacement. part 2: sar studies of 5-heteroalkyl substituted tcat derivatives
文献类型：期刊论文
| 作者 | Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ |
| 刊名 | Bioorganic & medicinal chemistry letters
 |
| 出版日期 | 2005-09-15 |
| 卷号 | 15期号:18页码:4130-4135 |
| 关键词 | Type i metaps inhibitors Bioisosteric replacement |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2005.06.005 |
| 通讯作者 | Li, j() |
| 英文摘要 | Systematic sar studies on the thiazole ring 5-substituent of tcat derivatives revealed that the introduction of a beta-alkoxy or an amino group enhanced the inhibitory activity significantly. the present compounds are representative of specific co(ii)-metap1 inhibitors. before the physiologically relevant metal ions for metaps are established, these small molecular compounds could be used as tools for detailed biological studies. (c) 2005 elsevier ltd. all rights reserved. |
| WOS关键词 | PYRIDINE-2-CARBOXYLIC ACID THIAZOL-2-YLAMIDE ; METHIONINE AMINOPEPTIDASE ; ESCHERICHIA-COLI ; SACCHAROMYCES-CEREVISIAE ; FUMAGILLIN ; PROTEINS ; GENE |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000231493400029 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377797 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Inst Mat Med,Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Univ Kansas, High Throughput Screening Lab, Lawrence, KS 66047 USA |
| 推荐引用方式 GB/T 7714 | Cui, YM,Huang, QQ,Xu, J,et al. Identification of potent type i metaps inhibitors by simple bioisosteric replacement. part 2: sar studies of 5-heteroalkyl substituted tcat derivatives[J]. Bioorganic & medicinal chemistry letters,2005,15(18):4130-4135. |
| APA | Cui, YM.,Huang, QQ.,Xu, J.,Chen, LL.,Li, JY.,...&Nan, FJ.(2005).Identification of potent type i metaps inhibitors by simple bioisosteric replacement. part 2: sar studies of 5-heteroalkyl substituted tcat derivatives.Bioorganic & medicinal chemistry letters,15(18),4130-4135. |
| MLA | Cui, YM,et al."Identification of potent type i metaps inhibitors by simple bioisosteric replacement. part 2: sar studies of 5-heteroalkyl substituted tcat derivatives".Bioorganic & medicinal chemistry letters 15.18(2005):4130-4135. |
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来源：中国科学院大学
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