In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial
文献类型：期刊论文
| 作者 | Li, HY; Chang, J; Cao, AM; Wang, JY |
| 刊名 | Macromolecular bioscience
 |
| 出版日期 | 2005-05-23 |
| 卷号 | 5期号:5页码:433-440 |
| 关键词 | Alkaline phosphatase activity Biocompatibility Degradation Osteoblasts Poly(butylene succinate) |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.200400183 |
| 通讯作者 | Chang, j() |
| 英文摘要 | Poly(butylene succinate) (pbsu) can be easily synthesized by condensation polymerization of the starting materials of succinic acid and butan-1,4-diol. it has good degradability and possesses excellent processability. due to these advantages, pbsu was first evaluated in the present study for its potential application as a novel biomaterial. the in vitro biocompatibility of the pbsu was evaluated by monitoring proliferation and differentiation of osteoblasts cultured on the pbsu film substrates for different periods. the results showed that the pbsu was biocompatible as the osteoblasts could proliferate and differentiate on the pbsu plates. in addition, the hydrolytic degradation behavior of the pbsu films in the phosphate-buffered saline (pbs) was also investigated and the results suggested that the pbsu degraded in the pbs solution with the same behavior as that of the degradable poly(alpha-hydroxyesters). in addition to the biocompatibility and hydrolytic degradation, some physical properties, including hydrophilicity, and mechanical and thermal properties of the pbsu substrates, were also determined and the results revealed that the pbsu was hydrophilic and ductile with excellent processability. the biocom-patibility of the pbsu, together with the advantages of hydrolytic degradability, hydrophilicity, and excellent processability, indicated that. pbsu has the potential to be used as a biomaterial for tissue repair. |
| WOS关键词 | COMPOSITE SCAFFOLDS ; BUILDING-BLOCKS ; DEGRADATION ; ACID) ; CELLS ; POLYMERS ; POLY(EPSILON-CAPROLACTONE) ; DIFFERENTIATION ; ATTACHMENT ; COPOLYMER |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000229423100009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377824 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chang, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, Polymer Mat Lab, Shanghai 200032, Peoples R China 4.E China Normal Univ, Sch Biol Sci, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, HY,Chang, J,Cao, AM,et al. In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial[J]. Macromolecular bioscience,2005,5(5):433-440. |
| APA | Li, HY,Chang, J,Cao, AM,&Wang, JY.(2005).In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial.Macromolecular bioscience,5(5),433-440. |
| MLA | Li, HY,et al."In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial".Macromolecular bioscience 5.5(2005):433-440. |
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来源：中国科学院大学
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