Association of mthfr gene polymorphism c677t with susceptibility to late-onset alzheimer's disease
文献类型：期刊论文
| 作者 | Wang, BB; Jin, F; Kan, R; Ji, S; Zhang, CF; Lu, ZP; Zheng, CG; Yang, Z; Wang, L |
| 刊名 | Journal of molecular neuroscience
 |
| 出版日期 | 2005 |
| 卷号 | 27期号:1页码:23-27 |
| 关键词 | Late-onset alzheimer's disease Methylenetetrahydrofolate reductase (mthfr) Homocysteine Apolipoprotein e Polymorphism Chinese |
| ISSN号 | 0895-8696 |
| DOI | 10.1385/jmn:27:01:23 |
| 通讯作者 | Wang, l() |
| 英文摘要 | Increased total plasma homocysteine (t-hcy) levels are found to be associated with alzheimer's disease (ad). because the methylenetetrahydrofolate reductase (mthfr) gene encodes a key enzyme that influences the metabolism of homocysteine, it has been considered as a possible genetic risk factor for ad. although the mthfr gene c677t polymorphism has a significant impact on reducing enzyme activity and increasing t-hcy concentrations, the association between the c677t polymorphism and ad remains inconclusive. to determine whether the mthfr gene c677t polymorphism contributes to the risk for late-onset ad (load) in chinese, we have investigated 104 sporadic load patients and 130 healthy controls. the strong associations of the tt genotype and t-allele with load (p = 0.001, or = 5.73 95% cl 1.85-17.72, and p = 0.002, or = 1.89 95% cl 1.25-2.86) were found. after stratifying by apolipoprotein e allele 4 (apoe epsilon 4) status, increased load risks associated with the tt genotype only in the apoe 84 noncarriers (chi(2) = 8.92, df 1, p = 0.003) and with the t-allele in either group (chi(2) = 5.18, df = 1, p = 0.023 and chi(2) = 5.53, df 1, p = 0.019) were seen. these results suggest that as an apoe epsilon 4 allele-dependent risk factor, the mthfr gene c677t polymorphism is involved in developing load in chinese. |
| WOS关键词 | METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR ; ANGIOTENSIN-CONVERTING ENZYME ; PLASMA HOMOCYSTEINE ; COMMON MUTATION ; GENOME SCREEN ; RISK-FACTOR ; DEMENTIA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| WOS类目 | Biochemistry & Molecular Biology ; Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000231101600003 |
| 出版者 | HUMANA PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377839 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, L |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 3.Beijing Union Med Coll Hosp, Inst Geriatr, Med Genet Lab, Minist Hlth, Beijing 100730, Peoples R China 4.Jiangbin Hosp, Nanning 530021, Guangxi, Peoples R China 5.Inner Mongolia Univ, Fac Life Sci, Hohhot 010021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, BB,Jin, F,Kan, R,et al. Association of mthfr gene polymorphism c677t with susceptibility to late-onset alzheimer's disease[J]. Journal of molecular neuroscience,2005,27(1):23-27. |
| APA | Wang, BB.,Jin, F.,Kan, R.,Ji, S.,Zhang, CF.,...&Wang, L.(2005).Association of mthfr gene polymorphism c677t with susceptibility to late-onset alzheimer's disease.Journal of molecular neuroscience,27(1),23-27. |
| MLA | Wang, BB,et al."Association of mthfr gene polymorphism c677t with susceptibility to late-onset alzheimer's disease".Journal of molecular neuroscience 27.1(2005):23-27. |
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来源：中国科学院大学
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