Denervation-induced spatiotemporal upregulation of ephrin-a2 in the mouse hippocampus after transections of the perforant path
文献类型：期刊论文
| 作者 | Wang, Y; Ni, ZM; Zhou, CF |
| 刊名 | Febs letters
 |
| 出版日期 | 2005-02-14 |
| 卷号 | 579期号:5页码:1055-1060 |
| 关键词 | Ephrin-a2 Hippocampus Perforant path Axon sprouting Reactive synaptogenesis |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/j.febslet.2005.01.007 |
| 通讯作者 | Zhou, cf() |
| 英文摘要 | Transections of the entorhinal afferent fibers to hippocampus, perforant path (pp), result in the denervation in specific hippocampal subregions, which is followed by a series of plastic events including axon sprouting and reactive synaptogenesis. many growth-associated molecules are thought to participate in these events. in the present study, we proved the upregulation of ephrin-a2 in the denervated areas of the ipsilateral hippocampus following pp transections. interestingly, when the elevation of ephrin-a2 reached the maximum axon sprouting in the denervated areas almost finished, implying the possible inhibitory effect of ephrin-a2 on sprouting. in addition, ephrin-a2 expression was observed in synapses during reactive synaptogenesis, suggesting that this molecule might also be implicated in the formation and maturation of synapses in the denervated areas. (c) 2005 federation of european biochemical societies. published by elsevier b.v. all rights reserved. |
| WOS关键词 | ENTORHINAL CORTEX LESION ; ELECTRON-MICROSCOPIC ANALYSIS ; EPH FAMILY RECEPTORS ; DENTATE GYRUS ; ADULT-RAT ; NEURAL DEVELOPMENT ; REACTIVE SYNAPTOGENESIS ; TOPOGRAPHIC PROJECTION ; SYNAPTIC PLASTICITY ; SUPERIOR COLLICULUS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000227210600015 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377846 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, CF |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Physiol,Key Lab Neurobiol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Y,Ni, ZM,Zhou, CF. Denervation-induced spatiotemporal upregulation of ephrin-a2 in the mouse hippocampus after transections of the perforant path[J]. Febs letters,2005,579(5):1055-1060. |
| APA | Wang, Y,Ni, ZM,&Zhou, CF.(2005).Denervation-induced spatiotemporal upregulation of ephrin-a2 in the mouse hippocampus after transections of the perforant path.Febs letters,579(5),1055-1060. |
| MLA | Wang, Y,et al."Denervation-induced spatiotemporal upregulation of ephrin-a2 in the mouse hippocampus after transections of the perforant path".Febs letters 579.5(2005):1055-1060. |
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来源：中国科学院大学
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