The modulation effects of bmk i, an alpha-like scorpion neurotoxin, on voltage-gated na+ currents in rat dorsal root ganglion neurons
文献类型：期刊论文
| 作者 | Chen, J; Tan, ZY; Zhao, R; Feng, XH; Shi, J; Ji, YH |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2005-12-23 |
| 卷号 | 390期号:2页码:66-71 |
| 关键词 | Sodium channel Subtype Scorpion toxin |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2005.08.003 |
| 通讯作者 | Ji, yh() |
| 英文摘要 | The present study investigated the effects of bmk i, a na+ channel receptor site 3 modulator purified from the buthus martensi karsch (bmk) venom, on the voltage-gated sodium currents in dorsal root ganglion (drg) neurons. whole-cell patch-clamping was used to record the tetrodotoxin-sensitive (ttx-s) and tetrodotoxin-resistant (ttx-r) components of voltage-gated na+ currents in small drg neurons. it was found that the inhibitory effect of bmk i on open-state inactivation of ttx-s na+ currents was stronger than that of ttx-r na+ currents. in addition, bmk i exhibited a selective enhancing effect on voltage-dependent activation of ttx-s currents, and an opposite effect on time-dependent activation of ttx-s and ttx-r na+ currents. the results suggested that the inhibitory effect of bmk i on open-state inactivation might contribute to the increase of peak ttx-s and ttx-r currents, and the enhancing effect of bmk i on time-dependent activation might also contribute to the increase of peak ttx-s currents. it was further suggested that a combined effect of bmk i including inhibiting the inactivation of ttx-s and ttx-r channels, accelerating activation and decreasing the activation threshold of ttx-s channels, might produce a hyperexcitability of small drg neurons, and thus contribute to the bmk i-induced hyperalgesia. (c) 2005 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; SODIUM-CHANNEL ; AUXILIARY SUBUNIT ; VENOM ; INJECTION ; BINDING ; TOXIN |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000232999400002 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377847 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, YH |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Inst Biol Sci, Shanghai Inst Physiol, Grad Sch, Shanghai, Peoples R China 3.Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA |
| 推荐引用方式 GB/T 7714 | Chen, J,Tan, ZY,Zhao, R,et al. The modulation effects of bmk i, an alpha-like scorpion neurotoxin, on voltage-gated na+ currents in rat dorsal root ganglion neurons[J]. Neuroscience letters,2005,390(2):66-71. |
| APA | Chen, J,Tan, ZY,Zhao, R,Feng, XH,Shi, J,&Ji, YH.(2005).The modulation effects of bmk i, an alpha-like scorpion neurotoxin, on voltage-gated na+ currents in rat dorsal root ganglion neurons.Neuroscience letters,390(2),66-71. |
| MLA | Chen, J,et al."The modulation effects of bmk i, an alpha-like scorpion neurotoxin, on voltage-gated na+ currents in rat dorsal root ganglion neurons".Neuroscience letters 390.2(2005):66-71. |
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来源：中国科学院大学
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