Identification of natural compounds with antiviral activities against sars-associated coronavirus
文献类型：期刊论文
| 作者 | Li, SY; Chen, C; Zhang, HQ; Guo, HY; Wang, H; Wang, L; Zhang, X; Hua, SN; Yu, J; Xiao, PG |
| 刊名 | Antiviral research
 |
| 出版日期 | 2005-07-01 |
| 卷号 | 67期号:1页码:18-23 |
| 关键词 | Severe acute respiratory syndrome coronavirus (sars-cov) Drug screening Natural products Lycorine Lycoris radiata herb |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2005.02.007 |
| 通讯作者 | Tan, xh() |
| 英文摘要 | More than 200 chinese medicinal herb extracts were screened for antiviral activities against severe acute respiratory syndrome-associated coronavirus (sars-cov) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium inner salt (nits) assay for virus-induced cytopathic effect (cpe). four of these extracts showed moderate to potent antiviral activities against sars-cov with 50% effective concentration (ec50) ranging from 2.4 +/- 0.2 to 88.2 +/- 7.7 mu g/ml. out of the four, lycoris radiata was most potent. to identify the active component, l. radiata extract was subjected to further fractionation, purification, and cpe/mts assays. this process led to the identification of a single substance lycorine as an anti-sars-cov component with an ec50 value of 15.7 +/- 1.2 nm. this compound has a cc50 value of 14980.0 +/- 912.0 nm in cytotoxicity assay and a selective index (si) greater than 900. the results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-sars-cov drugs in the treatment of sars. (c) 2005 elsevier b.v. all rights reserved. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; LYCORIS-RADIATA HERB ; HONG-KONG ; ALKALOIDS ; OUTBREAK ; ASSAY |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| WOS类目 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000230288900003 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377867 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tan, XH |
| 作者单位 | 1.Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China 2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China 3.HD Biosci Co Ltd, Shanghai 201203, Peoples R China 4.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China 5.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, SY,Chen, C,Zhang, HQ,et al. Identification of natural compounds with antiviral activities against sars-associated coronavirus[J]. Antiviral research,2005,67(1):18-23. |
| APA | Li, SY.,Chen, C.,Zhang, HQ.,Guo, HY.,Wang, H.,...&Tan, XH.(2005).Identification of natural compounds with antiviral activities against sars-associated coronavirus.Antiviral research,67(1),18-23. |
| MLA | Li, SY,et al."Identification of natural compounds with antiviral activities against sars-associated coronavirus".Antiviral research 67.1(2005):18-23. |
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来源：中国科学院大学
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