Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro
文献类型：期刊论文
| 作者 | Wang, WX; Ji, YH |
| 刊名 | Journal of neuro-oncology
 |
| 出版日期 | 2005-05-01 |
| 卷号 | 73期号:1页码:1-7 |
| 关键词 | Apoptosis Bmk venom Channels Glioma Tumor inhibition |
| ISSN号 | 0167-594X |
| DOI | 10.1007/s11060-004-4205-6 |
| 通讯作者 | Ji, yh() |
| 英文摘要 | Malignant gliomas are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatment. recent progress on enhanced studies of ion channels involved in glioma cells shed new light on the investigation of glioma cell growth and proliferation. here we report bmk scorpion venom, a rich resource of various ion channels blockers/modulators, induces cell death of cultured malignant glioma u251-mg cells in vitro specifically at a dose of 10 mg/ml while shows no effect on human hepatocellular carcinoma cells and chinese hamster ovary cells. the glioma cell death was then determined as apoptosis using 4,6-diamidino-2-phenylindole staining and fluorescence-activated cell sorting analysis. after incubation with bmk venom for 32 and 40 h, 36.20% and 63.08% of u251-mg cells showed apoptosis. furthermore, bmk venom could significantly inhibit the tumor growth in vitro, which was assessed using u251-mg tumor xenografts on severe combined immunodeficiency mice. the tumor volume of the bmk venom treated mice is nearly 1/8 of that of control after 21 days, and the tumor weight is less than half of that of control. that bmk venom induces apoptosis and inhibits growth of glioma may result from the inhibition and/or modulation of various ion channels in glioma cells. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; GATED SODIUM-CHANNELS ; K+ CHANNEL ; POTASSIUM CHANNELS ; POSSIBLE MECHANISM ; NA+ CHANNELS ; BRAIN-TUMORS ; BK CHANNELS ; BMK ; RAT |
| WOS研究方向 | Oncology ; Neurosciences & Neurology |
| WOS类目 | Oncology ; Clinical Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000229578200001 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377930 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, YH |
| 作者单位 | 1.Chinese Acad Sci, Inst Physiol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, WX,Ji, YH. Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro[J]. Journal of neuro-oncology,2005,73(1):1-7. |
| APA | Wang, WX,&Ji, YH.(2005).Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro.Journal of neuro-oncology,73(1),1-7. |
| MLA | Wang, WX,et al."Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro".Journal of neuro-oncology 73.1(2005):1-7. |
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来源：中国科学院大学
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