Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers
文献类型：期刊论文
| 作者 | Zhai, ZD; Zhang, H; Shi, YP; Chen, LR; Zhang, HL; Li, YM |
| 刊名 | Chinese journal of analytical chemistry
 |
| 出版日期 | 2005 |
| 卷号 | 33期号:1页码:109-112 |
| 关键词 | Enantiomer separation Semipreparative high performance liquid chromatography Albendazole sulfoxide Amylose tris(3,5-dimethylphenyl carbamate) |
| ISSN号 | 0253-3820 |
| 通讯作者 | Chen, lr() |
| 英文摘要 | A chiral stationary phase (csp) was prepared by coating amylose tris ( 3 5-dimethyl-phenyl carbamate) (admpc) onto aminopropylated spherical silica gel. broad spectrum anthelmintic agent-albendazole sulfoxide (abzso) was directly resolved on analytical admpc-csp column by normal-phase high performance liquid chromatography (hplc). then, the analytical methods were scaled up to semipreparative loading to obtain small quantities of both abzso enantiomers. especially, different loading amounts were investigated for their effect on various parameters of semipreparative hplc. using the maximum loading, about 1 g of each enantiomer were obtained in 83 h. a purity of > 99.9% and a yield of > 98. 0% was obtained for (+) abzso enantiomer; and a purity of > 99.0% and a yield of > 94. 0% was obtained for (-) abzso enantiomer. |
| WOS关键词 | ENANTIOSELECTIVE ANALYSIS ; PLASMA ; SILICA |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000226805000029 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377941 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, LR |
| 作者单位 | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.First Affiliated Hosp, Lanzhou Med Coll, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhai, ZD,Zhang, H,Shi, YP,et al. Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers[J]. Chinese journal of analytical chemistry,2005,33(1):109-112. |
| APA | Zhai, ZD,Zhang, H,Shi, YP,Chen, LR,Zhang, HL,&Li, YM.(2005).Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers.Chinese journal of analytical chemistry,33(1),109-112. |
| MLA | Zhai, ZD,et al."Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers".Chinese journal of analytical chemistry 33.1(2005):109-112. |
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来源：中国科学院大学
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